DOI: 10.1101/476382Nov 25, 2018Paper

Topological gene-expression networks recapitulate brain anatomy and function

BioRxiv : the Preprint Server for Biology
Alice PataniaGiovanni Petri

Abstract

Understanding how gene expression translates to and affects human behaviour is one of the ultimate aims of neuroscience. In this paper, we present a pipeline based on Mapper, a topological simplification tool, to produce and analyze genes co-expression data. We first validate the method by reproducing key results from the literature on the Allen Human Brain Atlas, and the correlations between resting-state fMRI and gene co-expression maps. We then analyze a dopamine-related gene-set and find that co-expression networks produced by Mapper returned a structure that matches the well-known anatomy of the dopaminergic pathway. Our results suggest that topological network descriptions can be a powerful tool to explore the relationships between genetic pathways and their association with brain function and its perturbation due to illness and/or pharmacological challenge.

Related Concepts

Blood - Brain Barrier Anatomy
Brain
Dopamine
Pharmacotherapy
Gene Expression
Genes
Literature
Software Tools
Genetic Activator
Description

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