Topological optimization for designing patient-specific large craniofacial segmental bone replacements.

Proceedings of the National Academy of Sciences of the United States of America
Alok SutradharTam H Nguyen

Abstract

Restoring normal function and appearance after massive facial injuries with bone loss is an important unsolved problem in surgery. An important limitation of the current methods is heuristic ad hoc design of bone replacements by the operating surgeon at the time of surgery. This problem might be addressed by incorporating a computational method known as topological optimization into routine surgical planning. We tested the feasibility of using a multiresolution three-dimensional topological optimization to design replacements for massive midface injuries with bone loss. The final solution to meet functional requirements may be shaped differently than the natural human bone but be optimized for functional needs sufficient to support full restoration using a combination of soft tissue repair and synthetic prosthetics. Topological optimization for designing facial bone tissue replacements might improve current clinical methods and provide essential enabling technology to translate generic bone tissue engineering methods into specific solutions for individual patients.

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Citations

Dec 4, 2012·Nanomedicine·Shaolie S HossainPaolo Decuzzi
Dec 15, 2015·Medical & Biological Engineering & Computing·Alok SutradharGlaucio H Paulino
Jul 10, 2016·International Journal of Computer Assisted Radiology and Surgery·Stefan RaithHorst Fischer
Oct 10, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shuo ZhangJerry Y H Fuh
Dec 12, 2018·PloS One·Kalenia Márquez-FlórezDiego Garzón-Alvarado
Mar 1, 2019·International Journal for Numerical Methods in Biomedical Engineering·Jaejong ParkAlok Sutradhar
Aug 27, 2013·Expert Review of Medical Devices·Andrés Díaz LantadaJavier Urbieta Sotillo
Sep 5, 2020·Biomedical Engineering Online·Marjan Bahraminasab
Feb 7, 2018·Computers in Biology and Medicine·Jaejong ParkGlaucio H Paulino

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