Topological organization of the human brain functional connectome across the lifespan

Developmental Cognitive Neuroscience
Miao CaoYong He

Abstract

Human brain function undergoes complex transformations across the lifespan. We employed resting-state functional MRI and graph-theory approaches to systematically chart the lifespan trajectory of the topological organization of human whole-brain functional networks in 126 healthy individuals ranging in age from 7 to 85 years. Brain networks were constructed by computing Pearson's correlations in blood-oxygenation-level-dependent temporal fluctuations among 1024 parcellation units followed by graph-based network analyses. We observed that the human brain functional connectome exhibited highly preserved non-random modular and rich club organization over the entire age range studied. Further quantitative analyses revealed linear decreases in modularity and inverted-U shaped trajectories of local efficiency and rich club architecture. Regionally heterogeneous age effects were mainly located in several hubs (e.g., default network, dorsal attention regions). Finally, we observed inverse trajectories of long- and short-distance functional connections, indicating that the reorganization of connectivity concentrates and distributes the brain's functional networks. Our results demonstrate topological changes in the whole-brain functional...Continue Reading

References

Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
May 1, 1997·Electroencephalography and Clinical Neurophysiology·J Polich
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Kirschner, J Gerhart
May 5, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A R ClarkeM Selikowitz
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
May 4, 2002·Science·Sergei Maslov, Kim Sneppen
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
Feb 24, 2006·Journal of Cognitive Neuroscience·Cheryl L GradyGordon Winocur
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·M E J Newman
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Aug 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Damien A FairBradley L Schlaggar
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Dec 7, 2007·Neuron·Jessica R Andrews-HannaRandy L Buckner
Dec 8, 2007·Cerebral Cortex·J S DamoiseauxS A R B Rombouts
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip ShawSteve P Wise
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
May 5, 2009·PLoS Computational Biology·Damien A FairSteven E Petersen
Jun 6, 2009·Current Opinion in Neurology·Danielle S Bassett, Edward T Bullmore
Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den HeuvelHilleke E Hulshoff Pol
Jul 25, 2009·Science·Carter T Butts
Sep 22, 2009·Brain and Cognition·Beatriz LunaKirsten O'Hearn
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Nov 17, 2009·NeuroImage·Michael W ColeWalter Schneider
Dec 2, 2009·Frontiers in Neuroinformatics·David MeunierEdward T Bullmore
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gaolang GongAlan C Evans
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Jan 7, 2010·Cerebral Cortex·M R AsatoB Luna
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Jun 29, 2010·Current Opinion in Neurology·Yong He, Alan Evans
Jul 2, 2010·Frontiers in Systems Neuroscience·Alex FornitoEdward T Bullmore
Jul 6, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C J Stam

❮ Previous
Next ❯

Citations

Apr 4, 2014·Obstetrics and Gynecology International·A Jensen
Jan 7, 2016·Cerebral Cortex·Fabien CignettiChristine Assaiante
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shi GuDanielle S Bassett
Feb 13, 2016·Frontiers in Aging Neuroscience·Jaime Gomez-RamirezJinglong Wu
Apr 15, 2015·NeuroImage·Alistair PerryMichael Breakspear
Dec 15, 2015·Brain Connectivity·Jo A ArcherShen-Hsing Annabel Chen
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Micaela Y ChanGagan S Wig
Mar 23, 2015·NeuroImage·Sean L Simpson, Paul J Laurienti
Apr 9, 2016·Computational Intelligence and Neuroscience·Wei LiXi Chen
Oct 3, 2015·NeuroImage·Richard F BetzelOlaf Sporns
Nov 28, 2015·Developmental Science·Kristafor Farrant, Lucina Q Uddin
Sep 28, 2015·Psychiatry Research·Tsung-Wei SuChing-Po Lin
Dec 3, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Petra E Vértes, Edward T Bullmore
Oct 17, 2015·Schizophrenia Bulletin·Julia M SheffieldDeanna M Barch
Apr 12, 2016·Frontiers in Neuroanatomy·Miao CaoYong He
Oct 2, 2015·Nature Communications·Shi GuDanielle S Bassett
Sep 19, 2014·Neuron·Adriana Di MartinoMichael P Milham
Jul 2, 2014·Developmental Cognitive Neuroscience·Russell A Poldrack
Mar 17, 2015·Developmental Cognitive Neuroscience·Diane Goldenberg, Adriana Galván
Mar 24, 2015·Developmental Cognitive Neuroscience·Kristafor Farrant, Lucina Q Uddin
Jul 15, 2015·Annual Review of Neuroscience·Beatriz LunaRajpreet Chahal
Jun 2, 2015·Frontiers in Human Neuroscience·Pedro ArizaJavier M Buldú
May 13, 2015·Translational Psychiatry·L JiangX-N Zuo
Oct 1, 2014·Applied Neuropsychology. Child·Leonard F KoziolSkip Hrin
Oct 1, 2014·Applied Neuropsychology. Child·Leonard F KoziolSkip Hrin
Apr 16, 2015·PloS One·Matthew L StanleyPaul J Laurienti
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Sally RichmondSarah Whittle

❮ Previous
Next ❯

Software Mentioned

fMRI
Lifespan
Freesurfer
Brain Net Viewer
Connectome Computation System CCS
FSL
AFNI
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.