Topologically controlled hyaluronan-based gel coatings of hydrophobic grid-like scaffolds to modulate drug delivery

Colloids and Surfaces. B, Biointerfaces
M Arnal-PastorA Vallés Lluch

Abstract

Scaffolds based on poly(ethyl acrylate) having interwoven channels were coated with a hyaluronan (HA) hydrogel to be used in tissue engineering applications. Controlled typologies of coatings evolving from isolated aggregates to continuous layers, which eventually clog the channels, were obtained by using hyaluronan solutions of different concentrations. The efficiency of the HA loading was determined using gravimetric and thermogravimetric methods, and the hydrogel loss during the subsequent crosslinking process was quantified, seeming to depend on the mass fraction of hyaluronan initially incorporated to the pores. The effect of the topologically different coatings on the scaffolds, in terms of mechanical properties and swelling at equilibrium under different conditions was evaluated and correlated with the hyaluronan mass fraction. The potential of these hydrogel coatings as vehicle for controlled drug release from the scaffolds was validated using a protein model.

References

May 22, 2008·Tissue Engineering. Part a·Cristina Martínez-RamosJosé Miguel Soria
Jan 6, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fan LeeMotoichi Kurisawa
Nov 27, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Abdulkerim TemizEnsari Guneli
Jun 15, 2011·Journal of Colloid and Interface Science·M Arnal-PastorM Monleón Pradas
Aug 1, 2013·Colloids and Surfaces. B, Biointerfaces·Cristina González-GarcíaManuel Salmerón-Sánchez
Aug 13, 2013·Acta Biomaterialia·A Vallés-LluchM Monleón Pradas
Nov 13, 2013·Expert Review of Cardiovascular Therapy·Juan C ChachquesCarlos Semino
Feb 12, 2014·Biochimica Et Biophysica Acta·Davide VigettiAlberto Passi
Feb 14, 2014·Colloids and Surfaces. B, Biointerfaces·Seong Won KimEun Seong Lee
Mar 19, 2014·Tissue Engineering. Part C, Methods·Cristina Martínez-RamosManuel Monleón Pradas
Jun 10, 2014·Journal of Biomedical Materials Research. Part a·Jorge L Alió Del BarrioMaria P De Miguel
Jul 6, 2014·Colloids and Surfaces. B, Biointerfaces·Ju-Hwan ParkDae-Duk Kim
Apr 18, 2015·Colloids and Surfaces. B, Biointerfaces·Silvia TavazziAlessandro Borghesi

❮ Previous
Next ❯

Citations

Mar 23, 2020·The Journal of Chemical Physics·N Farahmand BafiS Dietrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Changjiang FanLijian Liu
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Faming ChenYan Jin
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Kuifeng LiXingdong Zhang
© 2022 Meta ULC. All rights reserved