Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats

Behavioural Brain Research
Julia JungnickelClaudia Grothe

Abstract

Many Parkinson's disease (PD) patients suffer from anxiety disorders, which often precede the onset of classical motor symptoms. So far, there is no evidence from randomized, placebo-controlled trials for successful treatment of anxiety in patients with PD. Grafts of fetal nigral neurons are currently explored as a restorative cell therapy for PD. In PD animal models, intrastriatal transplantations of embryonic dopaminergic neurons have been shown to ameliorate behavioral defects. In our previous study we showed that expanded and differentiated neural progenitors improved drug-induced rotation behavior and posture balance as a more complex motor task. However, it is not clear whether grafting of these cells affected spontaneous locomotor activity and anxiety-like behavior in 6-OHDA lesioned rats. Therefore, we analyzed behavior of control, lesioned, sham-transplanted, and transplanted rats using open field (OF) and elevated plus maze (EPM). After unilateral 6-OHDA lesion of the medial forebrain bundle, we observed reduced locomotor activity in the EPM (wall-rearing, entries in closed arms) in lesioned and sham-transplanted rats, which correlated with the loss of dopaminergic neurons and apomorphine-induced rotation behavior. Fu...Continue Reading

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D R BurtS H Snyder
Nov 1, 1992·Biological Reviews of the Cambridge Philosophical Society·S B Dunnett, T W Robbins
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·A P CruzF G Graeff
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Feb 18, 2005·Brain : a Journal of Neurology·Philippe RemyDavid Brooks
Nov 1, 2005·Neurobiology of Disease·Marco TimmerClaudia Grothe
Apr 6, 2007·Trends in Neurosciences·Anders Björklund, Stephen B Dunnett
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathalie BreysseDeniz Kirik
Nov 17, 2009·Lancet Neurology·Maria C Rodriguez-OrozJosé A Obeso

❮ Previous
Next ❯

Citations

Jan 10, 2016·Behavioural Brain Research·Katherine A O'ConnorDamian S Shin
Jun 12, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M HovakimyanO Schmitt
Nov 24, 2011·Neuroscience·J Bové, C Perier
Jun 20, 2012·The European Journal of Neuroscience·Hanna S Lindgren, Stephen B Dunnett
Jun 7, 2014·Behavioural Brain Research·Yan Ping HuiQiao Jun Zhang
Apr 8, 2017·Neuroscience·Katherine A O'ConnorDamian S Shin
Oct 27, 2018·Neuroscience and Biobehavioral Reviews·Fanny FaivreMichel Barrot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.