Abstract
Many Parkinson's disease (PD) patients suffer from anxiety disorders, which often precede the onset of classical motor symptoms. So far, there is no evidence from randomized, placebo-controlled trials for successful treatment of anxiety in patients with PD. Grafts of fetal nigral neurons are currently explored as a restorative cell therapy for PD. In PD animal models, intrastriatal transplantations of embryonic dopaminergic neurons have been shown to ameliorate behavioral defects. In our previous study we showed that expanded and differentiated neural progenitors improved drug-induced rotation behavior and posture balance as a more complex motor task. However, it is not clear whether grafting of these cells affected spontaneous locomotor activity and anxiety-like behavior in 6-OHDA lesioned rats. Therefore, we analyzed behavior of control, lesioned, sham-transplanted, and transplanted rats using open field (OF) and elevated plus maze (EPM). After unilateral 6-OHDA lesion of the medial forebrain bundle, we observed reduced locomotor activity in the EPM (wall-rearing, entries in closed arms) in lesioned and sham-transplanted rats, which correlated with the loss of dopaminergic neurons and apomorphine-induced rotation behavior. Fu...Continue Reading
References
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D R BurtS H Snyder
Nov 1, 1992·Biological Reviews of the Cambridge Philosophical Society·S B Dunnett, T W Robbins
Aug 9, 1991·Brain Research·F C ZhouJ Murphy
Feb 2, 1990·Science·O LindvallC D Marsden
Jan 8, 1986·Brain Research·T ZetterströmA Björklund
Jul 1, 1987·Neuroscience·R E StreckerA Björklund
Aug 1, 1985·Journal of Neuroscience Methods·S PellowM Briley
Aug 11, 1980·Brain Research·F HeftiR J Wurtman
Mar 1, 1994·Experimental Neurology·P J KarstaedtK Gale
Apr 1, 1994·Neuroscience·E Lynd-Balta, S N Haber
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·A P CruzF G Graeff
Nov 1, 1994·Neuroscience·G NikkhahA Björklund
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Apr 15, 2004·Experimental Neurology·Marco TimmerGuido Nikkhah
Feb 18, 2005·Brain : a Journal of Neurology·Philippe RemyDavid Brooks
Nov 1, 2005·Neurobiology of Disease·Marco TimmerClaudia Grothe
Apr 6, 2007·Trends in Neurosciences·Anders Björklund, Stephen B Dunnett
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathalie BreysseDeniz Kirik
Sep 27, 2008·Neuroscience·M T TadaieskyR N Takahashi
Jun 9, 2009·Cell Transplantation·Guido NikkhahAlmuth Brandis
Nov 17, 2009·Lancet Neurology·Maria C Rodriguez-OrozJosé A Obeso
Citations
Apr 30, 2013·Molecular Neurodegeneration·Miguel M CarvalhoAntónio J Salgado
Apr 1, 2014·Neuroscience·Y P HuiJ Liu
Jan 10, 2016·Behavioural Brain Research·Katherine A O'ConnorDamian S Shin
Jun 12, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M HovakimyanO Schmitt
Nov 24, 2011·Neuroscience·J Bové, C Perier
Jul 5, 2011·Journal of Neuroscience Methods·E M TorresS B Dunnett
Jun 20, 2012·The European Journal of Neuroscience·Hanna S Lindgren, Stephen B Dunnett
Mar 24, 2015·Neuropharmacology·Yi-Na SunJian Liu
Aug 14, 2013·Neurobiology of Disease·Regina RumpelClaudia Grothe
Jun 7, 2014·Behavioural Brain Research·Yan Ping HuiQiao Jun Zhang
Apr 8, 2017·Neuroscience·Katherine A O'ConnorDamian S Shin
May 6, 2019·Neurological Research·Kun Cheng LiuLi Zhang
Oct 27, 2018·Neuroscience and Biobehavioral Reviews·Fanny FaivreMichel Barrot
Feb 19, 2021·Journal of Chemical Neuroanatomy·Maryam Sadat JalaliAlireza Sarkaki
Jun 4, 2021·Neurological Research·Cheng Xue DuJian Liu
Aug 7, 2021·Toxins·Veronica AntipovaAndreas Wree
Jan 16, 2020·Neuropsychobiology·Yi-Fan JiangLi Zhang