Topotecan and liposomal doxorubicin in recurrent ovarian cancer: is sequence important?

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
J DupontP Sabbatini

Abstract

A variety of agents have emerged to treat patients with recurrent epithelial ovarian cancer (EOC). Most patients receive both topotecan (T) and liposomal doxorubicin (D); however, there are no data regarding the benefit of a sequence-D followed by T (DT) or T followed by D (TD). We identified 89 consecutive patients with recurrent EOC, who received both D and T from January 1994 to January 2004 at Memorial Hospital. We compared the duration of treatment, toxicity, and overall survival (OS) for patients who received either DT or TD. Sixty-four patients received DT, and 25 patients received TD. The groups were balanced regarding age, stage, surgical debulking, platinum sensitivity, prior therapy, and intervening drugs between D and T. Median numbers of cycles on DT and TD were seven and six, respectively (P= 0.61); there was no difference in duration based on platinum sensitivity. Removal from therapy for toxicity was similar, DT (22%) and TD (36%) (P= 0.18). Finally, there was no difference in median OS based on sequence, DT (18.28 months) and TD (17.75 months) (P= NS). Platinum sensitivity did not affect median OS based on sequence. Based on duration, toxicity, and OS there is no advantage of one sequence of D and T when treati...Continue Reading

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Citations

May 23, 2012·Investigational New Drugs·Nilesh A PatankarMarcel B Bally
Feb 16, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P SabbatiniJ Dupont
Jun 12, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I VergoteUNKNOWN ASSIST-1 Study Group
Jan 11, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nilesh A PatankarMarcel B Bally

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