TOPping up ATR activity

Cell
Jiri Bartek, Niels Mailand

Abstract

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

References

Jun 7, 2003·Science·Lee Zou, Stephen J Elledge
Jul 10, 2004·Cell·Christopher J Bakkenist, Michael B Kastan
Nov 19, 2004·Nature·Michael B Kastan, Jiri Bartek
May 18, 2005·DNA Repair·Valerie GarciaAntony M Carr
Jul 4, 2006·Plant & Cell Physiology·Hirotaka KumagaiHiroshi Kouchi

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Citations

Jul 27, 2007·Cell Biochemistry and Biophysics·Laura R BarkleyCyrus Vaziri
Aug 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hyuk-Jin Cha, Hyungshin Yim
Jul 9, 2008·Molecular and Cellular Biology·Masahiro HitomiDennis W Stacey
Jan 17, 2009·Cancer Research·Terry A BeermanMary M McHugh
Apr 8, 2014·American Journal of Respiratory and Critical Care Medicine·Vinicio A de Jesus PerezRoham T Zamanian
Nov 19, 2013·Molecular Cell·Jiadong WangZihua Gong

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