TOR pathway activation in Zea mays L. tissues: conserved function between animal and plant kingdoms.

Plant Signaling & Behavior
Verónica Garrocho-Villegas, Estela Sánchez de Jiménez

Abstract

In most non-photosynthetic eukaryotes it has been demonstrated a conserved signal transduction pathway, namely TOR-S6K, that coordinates growth and cell proliferation. This pathway targets the translational apparatus to induce selective translation of ribosomal mRNAs as well as stimulate the cell cycle transition through the G1/S phase. Thus, by activation of this pathway through environmental signals, nutrients, stress, or specific growth factors, such as insulin or insulin-like growth factors (IGF), this pathway allows organisms to regulate growth and cell division. In plants, evidence has shown that TOR protein has been highly conserved through evolution, being involved in growth and cell proliferation control as well. Particularly in maize, a peptide named ZmIGF has been found in actively growing tissues. It targets the maize TOR pathway at the same extent as insulin and, by doing so it induces growth, as well as ribosomal proteins and DNA synthesis. Thus, higher metazoans and plants seem to conserve similar biochemical paths to regulate cell growth through equivalent targets that conduce to activation of the TOR-S6K pathway. Recent research shows evidence that supports this proposal by uncovering the ZmIGF receptor in maiz...Continue Reading

References

Mar 4, 2000·The Biochemical Journal·B Vanhaesebroeck, D R Alessi
Aug 4, 2001·The Biochemical Journal·C García FloresE Sánchez de Jiménez
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benoît MenandChristophe Robaglia
Jan 14, 2004·Biochemistry·Homero Reyes de la CruzEstela Sánchez de Jiménez
Jul 24, 2004·Biochemical Society Transactions·C RobagliaC Meyer
Sep 17, 2005·Genes & Development·Igor RuvinskyOded Meyuhas
Jun 10, 2006·The EMBO Journal·David ShahbazianNahum Sonenberg
Apr 7, 2007·Trends in Biochemical Sciences·Maria E Giannakou, Linda Partridge
Oct 18, 2007·Molecular BioSystems·Lourdes Teresa Agredano-MorenoEstela Sánchez de Jiménez
Oct 20, 2010·Protein and Peptide Letters·Cesar David Rodríguez-LópezEstela Sánchez de Jiménez

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Citations

Dec 9, 2015·Plant & Cell Physiology·Ken Yokawa, František Baluška
Jun 29, 2013·Biochimie·J M Villa-HernándezL J Pérez-Flores

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