TOR pathway: linking nutrient sensing to life span

Science of Aging Knowledge Environment : SAGE KE
Pankaj Kapahi, Brian M Zid

Abstract

Recent studies point to an emerging role for the TOR (target of rapamycin) pathway in the regulation of life span. In this Perspective, we discuss the possibility that this pathway is an important modulator of nutrient-dependent changes in life span. Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates.

References

Apr 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Holliday
Sep 25, 1999·Science·J MontagneG Thomas
Sep 20, 2000·The Journal of Cell Biology·Y KamadaY Ohsumi
Nov 9, 2000·Genes & Development·H ZhangT P Neufeld
Nov 23, 2000·Nature·L Guarente, C Kenyon
Mar 27, 2001·The Journal of Biological Chemistry·J RohdeM E Cardenas
Apr 25, 2002·Nature Reviews. Genetics·Linda Partridge, David Gems
Oct 17, 2002·Genes & Development·Thomas RadimerskiGeorge Thomas
Nov 26, 2002·Current Biology : CB·Steven J Marygold, Sally J Leevers
Sep 25, 2003·Cell·Julien ColombaniPierre Léopold
Oct 11, 2003·Molecular Cell·Alykhan F ShamjiStuart L Schreiber
Dec 12, 2003·Science's STKE : Signal Transduction Knowledge Environment·Thurl E Harris, John C Lawrence
Dec 12, 2003·Nature·Tibor VellaiFritz Müller
May 25, 2004·The Journal of Biological Chemistry·Barbara MeissnerRalf Baumeister
Jun 10, 2004·Current Biology : CB·Pankaj KapahiSeymour Benzer
Jul 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Immo A HansenAlexander S Raikhel
Aug 7, 2004·Developmental Cell·Ryan C ScottThomas P Neufeld

❮ Previous
Next ❯

Citations

Feb 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nir Barzilai, Andrzej Bartke
Jun 21, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francine H EinsteinRadhika H Muzumdar
Mar 29, 2011·Cold Spring Harbor Perspectives in Biology·Rebecca C Taylor, Andrew Dillin
Jun 5, 2010·PLoS Genetics·Matthew A SchreiberSteven L McIntire
Jan 14, 2012·PloS One·Eugenia Villa-CuestaPhilip A Gruppuso
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sofia Chiatamone RanieriGiovambattista Pani
Jul 16, 2013·Clinics in Geriatric Medicine·Jocelyn Wiggins, Markus Bitzer
Jan 14, 2016·Biomolecules & Therapeutics·Nan WuDiyan Li
Mar 2, 2010·Current Opinion in Immunology·Erika L Pearce
Dec 29, 2015·Advances in Chronic Kidney Disease·Markus Bitzer, Jocelyn Wiggins
Jun 5, 2007·Mechanisms of Ageing and Development·Pedro GomesCecília Leão
Nov 7, 2014·Neuron·Jonathan O Lipton, Mustafa Sahin
Feb 3, 2007·Aging Cell·Kally Z PanPankaj Kapahi
Sep 8, 2007·EMBO Reports·Matt Kaeberlein
Aug 15, 2012·Immunological Reviews·Gerritje J W van der Windt, Erika L Pearce
Jun 11, 2010·European Journal of Clinical Investigation·Daniel L SmithDavid B Allison
Oct 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Matt Kaeberlein
Oct 21, 2014·Journal of Neurochemistry·Jill Bouchard, Saul A Villeda
Mar 29, 2014·Biological Reviews of the Cambridge Philosophical Society·Yuehua WeiMang-Hua Xu
Nov 14, 2012·Current Opinion in Cell Biology·Salah Mahmoudi, Anne Brunet
Dec 7, 2010·Experimental Gerontology·Subhash D Katewa, Pankaj Kapahi
Feb 20, 2014·Ageing Research Reviews·Davide BolignanoCarmine Zoccali
Jun 22, 2016·Brain Pathology·Susana CardosoPaula I Moreira
Aug 17, 2011·Nephron. Experimental Nephrology·Jocelyn Wiggins
Jan 6, 2017·Proceedings. Biological Sciences·Sara ArgandaAudrey Dussutour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.