TOR signalling and control of cell growth

Current Opinion in Cell Biology
G Thomas, M N Hall

Abstract

TOR, phosphatidylinositol 3-kinase, p70s6k, and 4E-BP1 have recently emerged as components of a major signalling pathway that is dedicated to protein translation and thus to cell growth. This pathway appears to be conserved, at least in part, in yeast, slime molds, plants, flies, and mammals. TOR and phosphatidylinositol 3-kinase control p70s6k and 4E-BP1, which, in turn, directly control the translation initiation machinery.

References

Aug 17, 1995·Nature·J Downward
Sep 22, 1994·Nature·L Hartwell
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S R von ManteuffelG Thomas
Jul 4, 1996·Nature·K Nasmyth
Jan 1, 1996·Molecular Biology of the Cell·N C BarbetM N Hall
Aug 23, 1996·Cell·E J Brown, S L Schreiber
Jun 1, 1996·Current Opinion in Immunology·R T Abraham
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A SchmidtM N Hall
Feb 21, 1997·Cell·T F FrankeL C Cantley
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J de la CruzP Linder
Jun 1, 1997·The EMBO Journal·H B JefferiesG Thomas
Jun 23, 1997·FEBS Letters·P CohenD A Cross
Jun 23, 1997·FEBS Letters·N Pullen, G Thomas

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Citations

Jul 31, 1998·Protein Science : a Publication of the Protein Society·C M Fletcher, G Wagner
Mar 19, 2009·European Journal of Applied Physiology·Stephan KlossnerMartin Flueck
Mar 31, 2005·Biochemical and Biophysical Research Communications·Takeshi YamashitaNobuo Sakaguchi
Jun 7, 2005·Mechanisms of Ageing and Development·Linda PartridgeWilliam Mair
Apr 23, 2004·Trends in Cell Biology·Duojia PanXinsheng Gao
Feb 5, 1999·Biochemical Pharmacology·Y Goldberg
Jan 12, 2001·FEMS Microbiology Reviews·J François, J L Parrou
Nov 21, 2002·Neurochemistry International·Joanna Sobiesiak-MirskaKatarzyna A Nałecz
Nov 3, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·J A Kiefer, M C Farach-Carson
Nov 8, 2001·Current Opinion in Cell Biology·N TaponI K Hariharan
Sep 12, 2000·Current Opinion in Genetics & Development·H Stocker, E Hafen
Feb 13, 2001·Current Opinion in Genetics & Development·D A Prober, B A Edgar
May 30, 2001·Current Opinion in Genetics & Development·C J Potter, T Xu
Apr 12, 2002·Trends in Endocrinology and Metabolism : TEM·Robert S Garofalo
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·B Raught, A C Gingras
Dec 26, 2001·Cytokine & Growth Factor Reviews·Jonathan M Ellery, Peter J Nicholls
Aug 3, 2006·Nature Reviews. Drug Discovery·Sandrine FaivreEric Raymond
Sep 20, 2005·Oncogene·M RoccioF J T Zwartkruis
Sep 22, 2000·The Biochemical Journal·S P DaviesP Cohen
Aug 3, 2002·European Journal of Biochemistry·Ulrike KrauseLouis Hue
Mar 23, 2005·The Journal of Biological Chemistry·Carsten SkurkKenneth Walsh
May 12, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Soon-Kyung HwangMyung-Haing Cho
Dec 12, 2001·Molecular Biology of the Cell·N S CutlerM E Cardenas
Jun 16, 2001·Molecular Biology of the Cell·B K BajgierA M Neiman
Jun 25, 2004·Molecular Biology of the Cell·Monika U Keller-SeitzMichael Fasullo
May 26, 1998·The EMBO Journal·M BickleM N Hall

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