PMID: 8943012Nov 26, 1996Paper

TOR2 is required for organization of the actin cytoskeleton in yeast

Proceedings of the National Academy of Sciences of the United States of America
A SchmidtM N Hall

Abstract

The Saccharomyces cerevisiae gene TOR2 encodes a putative phosphatidylinositol kinase that has two essential functions. One function is redundant with TOR1, a TOR2 homolog, and is required for signaling translation initiation and early G1 progression. The second essential function is unique to TOR2. Here we report that loss of the TOR2-unique function disrupts polarized distribution of the actin cytoskeleton. A screen for dosage suppressors of a dominant negative TOR2 allele identified TCP20/CCT6, encoding a subunit of the cytosolic chaperonin TCP-1 that is involved in the biogenesis of actin structures. Overexpression of TCP20 restores growth and polarized distribution of the actin cytoskeleton in a tor2 mutant. TCP20 overexpression does not restore growth in a tor1 tor2 double mutant. We suggest that the unique function of the phosphatidylinositol kinase homolog TOR2 is required for signaling organization of the actin cytoskeleton during the cell cycle. TOR2, via its two functions, may thus integrate temporal and spatial control of cell growth.

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Citations

Apr 15, 2006·Current Genetics·Bérangère Pinan-LucarréCorinne Clavé
May 20, 2004·Experimental Cell Research·Leise A BervenMichael F Crouch
Dec 2, 1999·Molecular and Cellular Endocrinology·N S CutlerM E Cardenas
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Aug 24, 2013·Journal of Proteome Research·Katarzyna CiesielskaBart Devreese
Nov 1, 2011·Nature Reviews. Drug Discovery·Don BenjaminMichael N Hall
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Estela Jacinto, Michael N Hall
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Sep 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Antonio BarquillaMiguel Navarro
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Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Hay-Oak Park, Erfei Bi
Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·José L Crespo, Michael N Hall

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