Toripalimab: First Global Approval

Drugs
Susan J Keam

Abstract

Toripalimab, a recombinant, humanized programmed death receptor-1 (PD-1) monoclonal antibody that binds to PD-1 and prevents binding of PD-1 with programmed death ligands 1 (PD-L1) and 2 (PD-L2), is being developed by Shanghai Junshi Bioscience Co., Ltd in China for the treatment of various cancers. In December 2018, based on positive efficacy results of a phase 2 trial and safety data from several clinical studies, toripalimab received conditional approval in China for the treatment of unresectable or metastatic melanoma that has failed previous systemic therapy. This article summarizes the milestones in the development of toripalimab leading to this first global approval for the treatment of unresectable or metastatic melanoma.

Associated Clinical Trials

References

Jul 27, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lu SiJun Guo
Jan 9, 2019·Bioscience, Biotechnology, and Biochemistry·Xiuyuan ZhangZhihong Huang
Sep 11, 2019·Mathematical Biosciences and Engineering : MBE·Zi Long ZhuangWei Qin
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P ZhangL Shen

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Citations

Mar 4, 2020·International Journal of Molecular Sciences·Caterina VivaldiLorenzo Fornaro
Apr 5, 2020·Journal of Hematology & Oncology·Chongxian PanLei Zheng
May 24, 2020·Dermatology and Therapy·Jingrong LinShixin Han
Oct 10, 2020·Expert Opinion on Pharmacotherapy·Chengwei Peng, Deirdre J Cohen
Sep 12, 2020·The Innovation·Mei FengShaokun Shu
Dec 31, 2020·Pharmaceuticals·Diederick J van DoornHeinz-Josef Klümpen
May 20, 2021·Journal of Experimental & Clinical Cancer Research : CR·Xiang-Yuan LuoXing-Xing He

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