Torque teno viral load reflects immunosuppression in paediatric kidney-transplanted patients-a pilot study.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Phoebe UhlKrisztina Rusai

Abstract

Chronic deterioration of kidney graft function is related to inadequate immunosuppression (IS). A novel tool to assess the individual net state of IS in transplanted patients might be the monitoring of Torque teno virus (TTV) viral load. TTV is a non-pathogen virus detectable in almost all individuals. TTV level in the peripheral blood has been linked to the immune-competence of its host and should thus reflect IS after solid organ transplantation. TTV plasma load was quantified monthly by RT-PCR for a period of 1 year in 45 kidney-transplanted children. Post-transplant time was at least 3 months. The relation of the virus DNA levels to IS and transplant-specific clinical and laboratory parameters was analysed longitudinally. TTV DNA was detectable in 94.5% of the plasma samples. There was a significant association with the post-transplant follow-up time as well as with the type of IS regimen, with lower virus loads in patients after longer post-transplant time and mTOR inhibitor-based IS. Furthermore, a significant positive correlation with the dose of prednisolone and mycophenolate mofetil was found. TTV levels show an association/correlation with the strength of IS. Further studies are needed in order to evaluate TTV measure...Continue Reading

References

Mar 1, 1985·The Journal of Pediatrics·G J Schwartz, B Gauthier
Nov 16, 2001·Annals of the New York Academy of Sciences·S ZhongP J Johnson
Jul 2, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Stephan W Aberle, Elisabeth Puchhammer-Stöckl
Mar 12, 2003·Journal of Medical Virology·Eva Merethe MoenBjørn Grinde
Mar 5, 2004·The Journal of Infectious Diseases·Christoph SteiningerElisabeth Puchhammer
Dec 1, 2006·Nephron. Clinical Practice·Lesley ReesRichard S Trompeter
Jan 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ulrike John, Markus J Kemper
Mar 25, 2008·The Pediatric Infectious Disease Journal·Massimo PifferiAttilio L Boner
Jun 21, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraGiorgio Palù
Oct 7, 2008·Virology Journal·Jennifer S GriffinSharon C Long
Sep 9, 2009·Virology Journal·Evgeny V VasilyevDenis V Rebrikov
Feb 18, 2011·Clinical and Vaccine Immunology : CVI·Fabrizio MaggiMauro Bendinelli
Feb 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Irene GörzerElisabeth Puchhammer-Stöckl
Aug 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J J KimS D Marks
Nov 19, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C YoungR G Collman
Apr 22, 2015·PloS One·Irene GörzerElisabeth Puchhammer-Stöckl
Jul 7, 2015·Current Opinion in Organ Transplantation·Maria Lucia L MadariagaJoren C Madsen
Jul 15, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Alexander C Wiseman
Sep 25, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Julie BrassardG Douglas Inglis
Apr 20, 2016·Pediatric Transplantation·Krisztina RusaiThomas Müller-Sacherer
Apr 21, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D FocosiF Maggi
Nov 24, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Irene GörzerElisabeth Puchhammer-Stöckl
Mar 7, 2017·Transplantation·Federico SimonettaUNKNOWN Swiss Transplant Cohort Study (STCS)
Oct 2, 2017·Seminars in Pediatric Surgery·Elizabeth Doby Knackstedt, Lara Danziger-Isakov
Oct 31, 2017·Pediatric Transplantation·Joshua A BlatterDavid Wang
Jun 30, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Dorian KulifajSophie Alain
Sep 21, 2018·Transplantation·Björn C FryeJoachim Müller-Quernheim
Oct 23, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mario Fernández-RuizJosé María Aguado
Oct 31, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Pablo RuizMiquel Navasa
Jan 23, 2019·The Journal of Infectious Diseases·Robert StrasslGregor Bond

❮ Previous
Next ❯

Citations

Oct 12, 2020·Archives of Virology·Elena A Lolomadze, Denis V Rebrikov
Oct 28, 2020·Expert Opinion on Drug Metabolism & Toxicology·Rasmus EhrenLutz T Weber
May 28, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ryszard Grenda
Jun 3, 2021·Pathogens·Lari PyöriäMaria F Perdomo
Dec 22, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Natalia RedondoMario Fernández-Ruiz

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

MS Excel
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.