Torque Teno Virus as a Potential Biomarker for Complications and Survival After Allogeneic Hematopoietic Stem Cell Transplantation.

Frontiers in Immunology
Amandine PradierEddy Roosnek

Abstract

Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missing. Quantification of in vivo replication of the ubiquitous, non-pathogenic virus Torque Teno Virus (TTV) has been reported in small series as a test to functionally evaluate the quality of post-transplant immune reconstitution. In the present study, we analyzed by quantitative PCR TTV titers in plasma samples from a large cohort of 168 allogeneic HSCT recipients. Our analysis confirms that TTV titers peaked at 100 days post-transplant, followed by progressive normalization thereafter. Negative correlation of TTV titers with T cell absolute numbers during the first year post-transplant points to the restoration of an active anti-TTV immunity. Univariable and multivariable linear regression analysis demonstrated that donor CMV positive serostatus, donor type and immune suppression resulting from GVHD treatment affected the restoration of anti-TTV immunity. Importantly, higher TTV titers at 100 days after transplantat...Continue Reading

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Citations

Oct 12, 2020·Archives of Virology·Elena A Lolomadze, Denis V Rebrikov
Feb 9, 2021·Frontiers in Immunology·Claudio AnnaloroFrancesco Onida
Aug 25, 2021·PloS One·Maria C Mendes-CorreaSteven S Witkin
Oct 22, 2021·Journal of Medical Virology·Gustaf LeijonhufvudBjörn Andersson
Jan 21, 2022·PloS One·Tania Regina Tozetto-MendozaSteven S Witkin
Dec 22, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Natalia RedondoMario Fernández-Ruiz

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT04198506

Software Mentioned

FlowJo
Prism
GraphPad
R

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