Torque teno virus dynamics during the first year of life

Virology Journal
Elena A TyschikGennady T Sukhikh

Abstract

Torque teno virus is a small chronically persisting circular negative ssDNA virus reaching near 100% prevalence. It is reported to be a marker for immune function in immunocompromised patients. The possibility of vertical maternal-fetal transmission remains controversial but incidence rate of TTV DNA in children increased with age. TTV dynamics well studied for allogeneic hematopoietic stem cell transplantation as a predictor of post-transplant complications but there is no viral proliferation kinetics data for other patient groups or healthy individuals. The aim of this study was to determine TTV dynamics during the first year of life of healthy infants. Ninety eight clinically healthy breastfeeding infants (1-12 months of age) were analyzed by quantitative PCR for the whole blood TTV load with the test sensitivity of about 1000 viral copies per milliliter of blood (total number of samples including repeatedly tested infants was 109). 67% of all analyzed samples were TTV-positive demonstrating significant positive correlation between age and TTV load (r = 0.81, p < 0.01). This is the first study to suggest that viral load increases during the first year of life reaching a plateau after 6 months with strong proliferation for th...Continue Reading

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Citations

May 1, 2020·World Journal of Gastroenterology : WJG·Vasiliy I ReshetnyakTatiana I Karlovich
Mar 20, 2020·FEMS Microbiology Reviews·Joanna Kaczorowska, Lia van der Hoek
Oct 12, 2020·Archives of Virology·Elena A Lolomadze, Denis V Rebrikov
Feb 25, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Salwa M ElwasifHussein Sheashaa
Mar 21, 2021·NPJ Genomic Medicine·Savannah MwesigwaNeil A Hanchard
Mar 27, 2021·Scientific Reports·María Cebriá-MendozaJosé M Cuevas
Aug 8, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Roy D Bloom, Joshua J Augustine
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Oct 22, 2021·Journal of Medical Virology·Gustaf LeijonhufvudBjörn Andersson
Dec 22, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Natalia RedondoMario Fernández-Ruiz

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

DTprime Real - Time PCR Cycler
GraphPad Prism

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