Torsade de pointes arrhythmias arise at the site of maximal heterogeneity of repolarization in the chronic complete atrioventricular block dog

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Albert DunninkM A Vos

Abstract

The chronic complete atrioventricular block (CAVB) dog is highly sensitive for drug-induced torsade de pointes (TdP) arrhythmias. Focal mechanisms have been suggested as trigger for TdP onset; however, its exact mechanism remains unclear. In this study, detailed mapping of the ventricles was performed to assess intraventricular heterogeneity of repolarization in relation to the initiation of TdP. In 8 CAVB animals, 56 needles, each containing 4 electrodes, were inserted in the ventricles. During right ventricular apex pacing (cycle length: 1000-1500 ms), local unipolar electrograms were recorded before and after administration of dofetilide to determine activation and repolarization times (RTs). Maximal RT differences were calculated in the left ventricle (LV) within adjacent electrodes in different orientations (transmural, vertical, and horizontal) and within a square of four needles (cubic dispersion). Dofetilide induced TdP in five out of eight animals. Right ventricle-LV was similar between inducible and non-inducible dogs at baseline (327 ± 30 vs. 345 ± 17 ms) and after dofetilide administration (525 ± 95 vs. 508 ± 15 ms). All measurements of intraventricular dispersion were not different at baseline, but this changed for...Continue Reading

References

Mar 20, 1987·The American Journal of Medicine·D M Roden, D H Iansmith
Sep 3, 2002·Computer Methods and Programs in Biomedicine·Mark PotseCornelis A Grimbergen
Mar 20, 2004·Journal of Cardiovascular Electrophysiology·Mark RestivoNabil El-Sherif
Jun 29, 2004·Basic Research in Cardiology·Kirsten D SchreinerWolfgang Schoels
Sep 22, 2005·Journal of Cardiovascular Electrophysiology·Jinqiu Liu, Kenneth R Laurita
Aug 28, 2007·The American Journal of Cardiology·Henriette Sloth PedersenUNKNOWN DIAMOND Study Group
Nov 21, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Charles Antzelevitch
Jun 3, 2008·Pharmacology & Therapeutics·Avram OrosMarc A Vos
Nov 17, 2010·Circulation. Arrhythmia and Electrophysiology·Mitsunori MaruyamaPeng-Sheng Chen
May 31, 2011·Circulation. Arrhythmia and Electrophysiology·Mohamed BoulaksilMarc A Vos
Sep 29, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Albert DunninkMarc A Vos
Mar 27, 2012·Progress in Biophysics and Molecular Biology·Michiel J JanseMichael R Rosen
Dec 3, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Min Soo ChoYou-Ho Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Albert DunninkM A Vos
Circulation Journal : Official Journal of the Japanese Circulation Society
Tetsushi Furukawa
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Junkui WangChangcong Cui
© 2022 Meta ULC. All rights reserved