Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

Clinical and Experimental Nephrology
Kanyu MiyamotoHirokazu Imai

Abstract

We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia. He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy. After taking him off all drugs and administering spironolactone supplemented with potassium, his low serum potassium level was ameliorated. Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.

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Citations

Nov 28, 2012·Therapeutic Advances in Endocrinology and Metabolism·Hesham R OmarEnrico M Camporesi
Oct 16, 2015·Phytotherapy Research : PTR·Hossein Hosseinzadeh, Marjan Nassiri-Asl
Sep 27, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Li LiuMasakazu Yamagishi
Nov 24, 2016·Zeitschrift für Gerontologie und Geriatrie·Galia JackobsonDan Justo
Feb 15, 2020·Translational and Clinical Pharmacology·Hyun Kuk Kim, Sung Soo Kim
Apr 27, 2018·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Ayako KojimaKeizo Umegaki

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