Total activin A in maternal blood as a marker of preterm delivery in low-risk asymptomatic patients

Prenatal Diagnosis
Antonio FarinaNicola Rizzo

Abstract

To retrospectively evaluate whether increased serum levels of total activin A (t-activin A) are found in women who subsequently experience preterm delivery (PTD). Data on maternal serum t-activin A concentrations were available from a total of 84 singleton pregnant women and included 14 PTD pregnancies, each matched for gestational age and length of freezer storage, with 5 control pregnancies having term delivery (TD). Analyte values were expressed as multiple(s) of the control median. The median t-activin A for controls and cases was 1.00 +/- 0.45 and 1.27 +/- 0.53 MoM, respectively. Univariate analysis of the MoM values was performed using the Kaplan-Meier algorithm. Differences in the rate of delivery using a t-activin A MoM cut-off of > or = 1 SD (equivalent to 1.26 MoM) were analysed using the log rank test. The cumulative rate of PTD (< 37 weeks) was significantly higher for women with t-activin A concentrations > or = 1.26 MoM than those with t-activin A concentrations below this cut-off (40% vs.. 10%, p-value = 0.0218 log rank test). T-activin A concentration is higher in women who will develop PTD in a low-risk population. T-activin A values are inversely proportional to the time elapsed from blood test to delivery. Pr...Continue Reading

References

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Citations

Feb 2, 2008·Endocrinology·Pasquapina CiarmelaWylie Vale
Mar 16, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·A Conde-AgudeloJ Villar
Mar 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria De BonisFelice Petraglia

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