Total and allergen-specific immunoglobulin E in the serum and nasal mucosa of a nonallergic population

International Forum of Allergy & Rhinology
William R Reisacher

Abstract

There has been a growing interest in measuring allergen-specific immunoglobulin E (sIgE) directly from the nasal mucosal epithelium of individuals with sinonasal disease. However, there is currently no normative data with which to estimate sensitivity, specificity, and the appropriate positive cutoff level for new testing methods. Twenty individuals with no history of sinonasal disease or food allergies underwent serum IgE testing and nasal mucosal brush biopsy (MBB) testing for total and sIgE to 7 common airborne allergens and 1 food allergen. The correlation between sIgE in serum and nasal samples was determined at both the 0.10-kU/L and 0.35-kU/L positive cutoff levels. sIgE at the 0.35-kU/L cutoff level was detected for at least 1 allergen in 7 of 20 (35%) participants in both the serum and nose. At the 0.10-kU/L cutoff level, 8 of 20 (40%) and 19 of 20 (95%) participants had sIgE to at least 1 allergen in the serum and nose, respectively. At the 0.35-kU/L cutoff level, total serum IgE levels were significantly higher when at least 1 allergen was detected in the nose (p = 0.01). There was a strong association between sIgE in the serum and nasal mucosa (p < 0.0001) at both cutoff levels. The significant association between s...Continue Reading

References

Jan 1, 1985·Archives of Oto-rhino-laryngology·Y OhashiS Kihara
Jun 6, 1998·American Journal of Respiratory Cell and Molecular Biology·O GhaffarQ Hamid
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Pooja TakharHannah J Gould
Oct 29, 2008·American Journal of Rhinology·Sarah K WiseRodney J Schlosser
Jun 30, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Chadwick N AhnRodney J Schlosser
Apr 2, 2010·Allergy, Asthma & Immunology Research·Yang-Gi Min
Feb 9, 2012·International Forum of Allergy & Rhinology·William R Reisacher
Nov 9, 2012·International Forum of Allergy & Rhinology·William R Reisacher
Mar 23, 2013·International Forum of Allergy & Rhinology·William R Reisacher, Justin C Cohen
Jun 4, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Xiaowen ZhangGuangqiao Zeng
Jan 17, 2014·International Forum of Allergy & Rhinology·William R Reisacher, Maria G Bremberg
Nov 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helton da Costa SantiagoThomas B Nutman

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Citations

Jun 28, 2016·International Forum of Allergy & Rhinology·David W Kennedy
May 23, 2018·American Journal of Rhinology & Allergy·Erin C SaricilarRichard Harvey
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Oct 15, 2018·Current Allergy and Asthma Reports·Carmen RondónPaloma Campo
Sep 17, 2020·International Forum of Allergy & Rhinology·Wesley DavisonWilliam R Reisacher

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