Total and cardiovascular disease mortality predicted by metabolic syndrome is inferior relative to its components

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Robin HaringHenry Völzke

Abstract

This study examined the predictive role of metabolic syndrome (MetS) and its single components for total and cardiovascular disease (CVD) mortality. We analyzed data from 3,927 participants aged 20-79 years without history of CVD, recruited for the prospective population-based Study of Health in Pomerania (SHIP). During the mean 7.2 years (25 (th), 6.6; 75 (th): 8.0) of follow-up, 240 deaths (79 CVD deaths) occurred. MetS was defined by National Cholesterol Education Program Adult Treatment Panel III guidelines. The association of MetS with total and CVD mortality was analyzed by Cox proportional hazards regression models. The impact of single MetS components on survival time was compared using standardized beta coefficients from multivariable linear regression models. Baseline MetS prevalence was 28.8%. Age- and gender-adjusted Cox models revealed that participants with MetS had an increased risk of total mortality (hazard ratio (HR) 1.41; 95% confidence interval (95% CI) 1.09-1.82) and CVD mortality (HR 1.82; 95% CI 1.22-3.13) compared to participants without MetS. Of the single MetS components, participants with increased waist circumference (WC) and glucose levels exposed highest risk of total (HR 1.49; 95% CI 1.10-2.01; HR...Continue Reading

Citations

Mar 23, 2013·BMC Endocrine Disorders·Lisa BalbachRobin Haring
Jan 29, 2011·Cardiovascular Diabetology·Alexander Tenenbaum, Enrique Z Fisman
Jun 19, 2013·Asian Journal of Andrology·David J Handelsman
Mar 31, 2011·Langenbeck's Archives of Surgery·Michael PfeifferPeter P Nawroth
May 8, 2016·Diabetes/metabolism Research and Reviews·Atieh AmouzegarFereidoun Azizi
Jun 20, 2012·European Journal of Preventive Cardiology·Robin HaringHenri Wallaschofski
Oct 1, 2013·Journal of Hypertension·Henry VölzkeHeyo K Kroemer
Nov 27, 2018·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Dirk Müller-WielandKarl Wegscheider

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