Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load

Frontiers in Cellular and Infection Microbiology
Taowen ZhangXiaohui Rausch-Fan

Abstract

The detection of salivary biomarkers has a potential application in early diagnosis and monitoring of periodontal inflammation. However, searching sensitive salivary biomarkers for periodontitis is still ongoing. Oxidative stress is supposed to play an important role in periodontitis progression and tissue destruction. In this cross-sectional study, we investigated total antioxidant capacity (TAC) and total oxidant status (TOS) in saliva of periodontitis patients compared to healthy controls and their relationship with periodontopathic bacteria and periodontal disease severity. Unstimulated saliva was collected from 45 patients with generalized severe periodontitis and 37 healthy individuals and the TAC/TOS were measured. In addition, salivary levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum in saliva were measured. Salivary TAC was lower in periodontitis patients compared to healthy controls. Moreover, a significant negative correlation of salivary TAC with clinical attachment loss was observed in periodontitis patients. No significant difference in the salivary TOS was observed between periodontitis patients and healthy controls. ...Continue Reading

References

May 1, 1986·Journal of Clinical Periodontology·J M Goodson
Jul 1, 1983·Journal of Clinical Periodontology·J LindheS S Socransky
Nov 1, 1994·Free Radical Research·S MooreC A Rice-Evans
Mar 12, 1998·Journal of Clinical Periodontology·S S SocranskyR L Kent
Feb 1, 1995·Periodontology 2000·G C Armitage
Feb 1, 1995·Periodontology 2000·I B Lamster, J T Grbic
Jun 23, 2000·Annals of Periodontology·G C Armitage
Jul 29, 2000·Journal of Clinical Periodontology·E Kaufman, I B Lamster
Dec 21, 2000·Free Radical Biology & Medicine·A GhiselliC Scaccini
Aug 15, 2001·Acta Odontologica Scandinavica·G J Seymour, E Gemmell
Apr 10, 2002·Journal of Clinical Periodontology·M BattinoP Bullon
Apr 25, 2003·Journal of Periodontology·Ira B LamsterRobert E Singer
May 14, 2003·Clinical Oral Investigations·Randa Diab-LadkiRamez Chahine
Jun 12, 2004·Journal of Clinical Periodontology·G R BrockI L C Chapple
Feb 15, 2005·International Journal of Clinical Practice·K CharalabopoulosA Evangelou
Oct 11, 2005·Clinical Biochemistry·Ozcan Erel
Jan 12, 2007·Periodontology 2000·Iain L C Chapple, John B Matthews
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Oded HershkovichRafael M Nagler
Sep 14, 2007·Immunological Reviews·William M Nauseef
Jul 3, 2008·The Journal of the American Dental Association·Mahvash NavazeshUNKNOWN University of Southern California School of Dentistry
Apr 25, 2009·Periodontology 2000·William V GiannobileDavid T Wong
Apr 14, 2010·Biomarkers in Medicine·Craig S MillerJohn T McDevitt
May 11, 2010·Journal of Periodontology·Harlan J Shiau, Mark A Reynolds
Sep 28, 2010·Gender Medicine·Richard J Bloomer, Kelsey H Fisher-Wellman
Jan 12, 2011·Journal of Periodontology·Mine Öztürk TonguçF Yeşim Kırzıoğlu
Mar 17, 2011·Journal of Dental Research·J S KinneyW V Giannobile
Dec 7, 2011·Frontiers of Oral Biology·David A Scott, Jennifer Krauss
Jan 10, 2012·Oral Diseases·K BertlX Rausch-Fan
Jan 24, 2012·Journal of Periodontology·Hady HaririanXiaohui Rausch-Fan
Aug 1, 2012·Clinical Oral Investigations·Kristina BertlXiaohui Rausch-Fan
Sep 18, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Viera CelecováPeter Celec
Aug 21, 2013·Journal of Clinical Periodontology·Oleh AndrukhovXiaohui Rausch-Fan
Sep 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lubomíra TóthováPeter Celec
Oct 8, 2013·Journal of Dental Research·E Hajishengallis, G Hajishengallis
Dec 11, 2013·Periodontology 2000·Ali CekiciThomas E Van Dyke
Mar 29, 2014·Clinical Oral Investigations·Lenka BaňasováPeter Celec
Jan 1, 2013·SpringerPlus·Richard J Bloomer, Sang-Rok Lee
Apr 19, 2015·Free Radical Biology & Medicine·Jessica WangMervyn Gornitsky
Aug 8, 2015·Periodontology 2000·Joerg Meyle, Iain Chapple

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Citations

Nov 29, 2017·Frontiers in Physiology·Yue WangXiaohui Rausch-Fan
Jan 10, 2018·Frontiers in Physiology·L'ubomíra Tóthová, Peter Celec
Aug 22, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Farhad VahidSayed Hossein Davoodi

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Methods Mentioned

BETA
Assay
chip
DNA-Chip
MDA

Software Mentioned

CheckScanner
SPSS
Check Report

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