PMID: 11337012May 5, 2001Paper

Total antioxidant levels, gender, and age as risk factors for DNA damage in lymphocytes of the elderly

Mechanisms of Ageing and Development
Víctor Manuel Mendoza-NúñezM A Altamirano-Lozano

Abstract

During past years, the association of oxidative stress with DNA damage and its possible clinical translation into chronic degenerative illnesses, such as atherosclerosis, cancer, diabetes mellitus and Alzheimer's disease, has been demonstrated. In addition, it has been pointed out that age and gender are factors that influence the generation of DNA damage; however, this is still controversial. We have previously reported the results of a study of 88 subjects older than 60 years of age in whom DNA damage is related with serum levels of total antioxidants. The results of this study demonstrate a greater frequency of DNA damage in elderly persons with normal levels of antioxidants, in addition to males, and in the younger group of subjects, i.e., 60-69 years. In this work, we enlarged our study sample to 160 elderly subjects; in this way, we were able to evaluate the consistency of the influence of total antioxidants, age, and gender on the magnitude and grade of DNA damage in lymphocytes of the elderly. The results demonstrated that 45% of the subjects showed DNA damage, measured by an alkaline unicellular electrophoresis technique (comet assay). Similarly, 62% of the subjects presented low levels of total antioxidant levels meas...Continue Reading

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Citations

Feb 20, 2003·Developmental and Comparative Immunology·Noelia Guayerbas, Mónica De La Fuente
Apr 23, 2003·Molecular and Cellular Endocrinology·Patricia MerkelRiccardo Perfetti
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