Total antioxidant status correlates with cognitive impairment in patients with recurrent depressive disorder.

Neurochemical Research
M TalarowskaEdward Kowalczyk

Abstract

Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive performance. the study comprised 74 subjects: patients with rDD (n = 45) and healthy subjects (n = 29). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test and Auditory Verbal Learning Test. Statistically significant differences were found in the intensity of depression symptoms, measured by the Hamilton Depression Rating Scale (HDRS) on therapy onset versus the examination results after 8 weeks of treatment (p < 0.001). The level of TAS was substantially higher in patients with rDD (p = 0.01). For rDD patients, elevated TAS levels were associated with worse cognitive test performance. The higher was the concentration of plasma TAS, the greater was the severity of depressive symptoms measured by HDRS before and after pharmacotherapy. (1) Higher concentration of plasma TAS in rDD patients is associated with the severity of depressive symptoms. (2) Elevated levels of plasma TAS ...Continue Reading

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Citations

Jan 7, 2014·Psychiatry Research·Piotr GałeckiJanusz Szemraj
Jan 25, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Monika TalarowskaPiotr Gałecki
Jun 3, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Monika TalarowskaPiotr Gałecki
Feb 13, 2016·Advances in Medical Sciences·Elżbieta GałeckaJanusz Szemraj
Feb 10, 2016·Acta Neuropsychiatrica·Kinga BobińskaMonika Talarowska
Dec 19, 2015·BioMed Research International·Cheng MaZhuowei Yu
Aug 1, 2014·Journal of Neural Transmission·Krzysztof KrystaIrena Krupka-Matuszczyk
May 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr GałeckiMichael Maes
Jul 20, 2014·Advances in Medical Sciences·Monika TalarowskaPiotr Gałecki
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Jun 29, 2017·International Clinical Psychopharmacology·Siu W TangBrain E Leonard

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