Total antioxidant status of zinc, manganese, copper and selenium levels in rats exposed to premium motor spirit fumes.

North American Journal of Medical Sciences
Patrick OkuonghaeMoses Igbinuwen

Abstract

Frequent exposure to premium motor spirit (PMS) is common and could be a risk factor for liver dysfunction in those occupationally exposed. A possible association between PMS fumes and plasma total antioxidant status as well as plasma levels of zinc, manganese, copper and selenium using a rodent model could provide new insights into the pathology of the liver where cellular dysfunction is an established risk factor. This study aimed to determine the total antioxidant status and plasma levels of zinc, copper, selenium and manganese in those occupationally exposed using rodent model. 25 albino Wistar rats of both sexes were used for this study. The animals were divided into five groups of five rats in each group. Group 1 rats were not exposed to PMS fumes (control group), group 2 rats were exposed for 1 hour daily, group 3 for 3 hours daily, group 4 for 5 hours daily and group 5 for 7 hours daily. The experiment lasted for a period of 4 weeks. Blood samples obtained from all the groups after 4 weeks of exposure were used for the determination of plasma total antioxidant status as well as plasma levels of zinc, manganese, copper and selenium. Results showed significant increases in means of plasma copper (69.70±0.99 for test and 6...Continue Reading

Citations

Jul 11, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Irena MusikJoanna Kocot
Nov 30, 2013·Seminars in Arthritis and Rheumatism·Yuan Z LimFlavia M Cicuttini
Oct 8, 2017·Chinese Journal of Integrative Medicine·Suresh KumarNeeru Vasudeva

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.