Total artificial heart implantation as a bridge to transplantation: a viable model for the future?

Expert Review of Medical Devices
Rachel A BeaupréJeffrey A Morgan

Abstract

Since the first total artificial heart (TAH) surgery in a human patient performed in 1969, over 1300 devices have been implanted worldwide. Patients are benefiting from increased lengths of durable support and indications have expanded beyond biventricular failure including allograft failure, severe restrictive disease, and complex congenital anomalies. Areas covered: The role of the TAH in biventricular failure, rates of successful bridge-to-transplant (BTT), and survival compared with biventricular assist devices (BiVADs) are discussed and differences between TAH and LVAD patient populations are highlighted. The device's niche role in physiologies not amenable to single ventricle support is further described. New developments such as the 50cc Syncardia, continuous flow mechanisms (BiVACOR and Cleveland Clinic CF-TAH), and a bioprosthetic model (CARMAT) are discussed. Literature review was conducted utilizing the PubMed database selecting published research, database analyses, and case reports under 'total artificial heart' relevant to the paper's aims. Expert commentary: TAH patients have high rates of successful BTT and survival on par with BiVAD-supported patients. Ongoing developments including decreased device size, conti...Continue Reading

References

Jul 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jack G CopelandMarvin J Slepian
Aug 3, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorMarshall I Hertz
Jan 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·Jack G CopelandMark Friedman
Aug 28, 2012·Seminars in Thoracic and Cardiovascular Surgery·David L S MoralesIki Adachi
Apr 9, 2013·The Annals of Thoracic Surgery·Matthias E W KirschPascal Leprince
Nov 28, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·William E CohnO H Frazier
Apr 4, 2014·The Annals of Thoracic Surgery·Joseph W RossanoJ William Gaynor
Jul 30, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kristin L ThanavaroKeyur B Shah
Mar 26, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jamshid H KarimovNader Moazami
Oct 27, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Sergey P GlyantsevLeo A Bockeria
Jan 29, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gino GerosaVincenzo Tarzia
Feb 24, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryan A MooreDavid L S Morales
Mar 25, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elizabeth D BlumeUNKNOWN PediMACS Investigators
Nov 5, 2016·Journal of Cardiac Failure·Keyur B ShahVigneshwar Kasirajan
Nov 3, 2016·Medical Science Monitor Basic Research·Jamila KremerAlexander Weymann
Dec 24, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·David L S MoralesChet R Villa
Mar 30, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masashi KawaboriJeffrey A Morgan
Apr 4, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christina J VanderPluymElizabeth D Blume
May 26, 2017·Frontiers in Physiology·Chet R Villa, David L S Morales
Jun 27, 2017·Journal of Cardiothoracic and Vascular Anesthesia·David M SmadjaAlain Carpentier
Sep 21, 2017·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Anthony NguyenMichel Carrier
Sep 26, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinDavid C Naftel
Oct 8, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian LatrémouilleDavid M Smadja
Jan 25, 2018·Interactive Cardiovascular and Thoracic Surgery·Kiyotaka FukamachiNader Moazami
Apr 5, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kiyotaka FukamachiDavid J Horvath
Apr 29, 2018·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jamshid H KarimovKiyotaka Fukamachi
May 11, 2018·Clinical Transplantation·Rodolfo D BenattiGuilherme H Oliveira
May 29, 2018·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Francisco A ArabíaJames K Kirklin

❮ Previous
Next ❯

Citations

May 24, 2019·Circulation Research·Leslie MillerO H Frazier
Apr 18, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Richard N PiersonDavid A D'Alessandro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Current Opinion in Cardiology
Vigneshwar KasirajanKeyur B Shah
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Ryan A MooreDavid L S Morales
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Matthias KirschGroupe de Réflexion sur l'Assistance Mécanique
© 2022 Meta ULC. All rights reserved