Total-body contrast-enhanced MRA on a short, wide-bore 1.5-T system: intra-individual comparison of Gd-BOPTA and Gd-DOTA.

European Radiology
M RasmusD Bilecen

Abstract

Total-body contrast-enhanced MRA (CE-MRA) provides information of the entire vascular system according to a one-stop-shop approach. Short, wide-bore scanners have not yet been used for total-body CE-MRA, probably due to their restricted field of view in the z-direction. The purpose of this feasibility study is to introduce an image protocol for total-body MRA on a short, wide-bore system. The protocol includes five to six table-moving steps and two injection runs. Two pharmacologically different contrast materials (CM) were applied in ten healthy volunteers in view of possible CM-dependent influences on the protocol outcome (Gd-Bopta, Gd-Dota). Differences consisted of significantly higher CNR with Gd-Bopta with a mean of 73.8+/-38.7 versus 69.1+/-34.3 (p=0.008), significantly better arterial visualization values with Gd-Dota with a mean of 1.26+/-0.44 versus 1.53+/-0.73 (p=0.003) and a tendency to less venous overlay with Gd-Dota, mean 1.19+/-0.44 and 1.34+/-0.72, respectively (p=0.065) (two-tailed Wilcoxon matched-pairs test). Overall 94% of the steps were valued as qualitatively excellent or good. The good results with both CM suggest a transfer to further patient evaluation.

References

Oct 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M MagerstädtM Naegele
Nov 18, 1998·Investigative Radiology·M A KirchinA Spinazzi
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David G KrugerPhillip J Rossman
Mar 29, 2003·European Radiology·James F M Meaney
Sep 30, 2003·Journal of Vascular and Interventional Radiology : JVIR·Nilesh PatelUNKNOWN Society of Interventional Radiology Technology Assessment Committee
May 20, 2004·AJR. American Journal of Roentgenology·Christoph U HerbornJörg F Debatin
Jul 23, 2004·Journal of Magnetic Resonance Imaging : JMRI·Deniz BilecenKurt A Jäger
Feb 18, 2005·Radiology·Oliver A MeissnerStefan O Schoenberg
Apr 19, 2005·Journal of Magnetic Resonance Imaging : JMRI·Michael FenchelStephan Miller
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Apr 6, 2006·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·C KlessenM Taupitz
Sep 21, 2006·AJR. American Journal of Roentgenology·Thomas M GlueckerDeniz Bilecen

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Citations

Mar 20, 2009·Cardiovascular and Interventional Radiology·Yousef W NielsenHenrik S Thomsen
Oct 1, 2008·Angewandte Chemie·Eric J WernerKenneth N Raymond

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