Total-body irradiation--role and indications: results from the German Registry for Stem Cell Transplantation (DRST)

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Frank HeinzelmannClaus Belka

Abstract

Total-body irradiation (TBI) is a key part of the conditioning regimen before hematopoietic stem cell transplantation (HSCT). The exact role of TBI as part of the conditioning regimen is largely unclear. In order to determine the relevance of TBI, the status of TBI utilization was analyzed on the basis of a nationwide registry. 14,371 patients (1998-2002) documented in the German Stem Cell Transplantation Registry (DRST) were analyzed regarding TBI utilization prior to autologous or allogeneic transplantation, underlying disorder, type of donor, stem cell source, and size of the treatment center. For autologous HSCT approximately 10% of the patients (873/8,167) received TBI, with chronic lymphocytic leukemia (CLL, approximately 80%, 171/214) and low-grade non-Hodgkin's lymphoma (l-NHL, approximately 35%, 330/929) being the most important disorders. In the allogeneic setting 50% of the patients (2,399/4,904) received TBI, with acute lymphocytic leukemia (ALL, 85%, 794/930), acute myeloid leukemia (AML, 45%, 662/1,487) and chronic myeloid leukemia (CML, 49%, 561/1,156) being the key indications. The type of donor, stem cell source and center size did not strongly influence the use of TBI. TBI has only a limited role for the condi...Continue Reading

Citations

Nov 10, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Johanna GersteinMichael Bremer
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank HeinzelmannMartin Weinmann
May 3, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tobias BöllingNormann Willich
Jun 16, 2015·Frontiers in Cell and Developmental Biology·Janne M Nestvold, Bent Rolstad
Jun 12, 2016·Radiation Oncology·Petra M HärtlBarbara Dobler
Oct 9, 2018·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Amir Ali HamidiehArdeshir Ghavamzadeh
Oct 20, 2020·International Journal of Radiation Oncology, Biology, Physics·Sara ChabiBenjamin Uzan

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