Total body irradiation dose optimization based on radiological depth.

Journal of Applied Clinical Medical Physics
Amjad HussainDerek Brown

Abstract

We have previously demonstrated the use of Eclipse fluence optimization to define aperture sizes for a novel aperture modulated translating bed total body irradiation (TBI) technique. The purposes of the present study were to identify, characterize, and correct for sources of error inherent in our previous fluence optimization technique, and to develop a clinically viable fluence optimization module for the translating bed TBI technique. Aperture modulated TBI is delivered by translating the patient at constant speed on a custom bed under a modulated radiation beam. The patient is then turned from supine to prone and the process repeated, resulting in an AP-PA treatment. Radiological depths were calculated along divergent ray lines through individual CT slices of a RANDO phantom. Beam apertures, defined using a dynamic multileaf collimator (DMLC), were generated using calculated radiological depths and calibration factors that relate fluence to aperture size in a dynamic environment. These apertures were defined every 9 mm along the phantom superior-inferior axis. The calculated beam apertures were further modified to account for scatter within the patient. For dose calculation purposes the individual MLC files were imported in...Continue Reading

References

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Apr 2, 2011·Medical Physics·Amjad HussainDerek W Brown

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Citations

Apr 14, 2016·Journal of Applied Clinical Medical Physics·Narottam LamichhaneMatthew T Studenski
Mar 23, 2017·Physics in Medicine and Biology·So-Yeon ParkJong Min Park
Aug 21, 2013·BioMed Research International·Ho-Hsing ChenJin-Ching Lin
Apr 14, 2016·Journal of Applied Clinical Medical Physics·Shahbaz AhmedAmjad Hussain
Jan 13, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E Hoseinnezhad ZarghaniT Hadisinia
Feb 23, 2021·Current Oncology·Mitchell SabloffRajiv Samant

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Software Mentioned

Eclipse
AM
RANDO
MATLAB
TBI

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