Total cardiovascular risk, blood pressure variability and adrenergic overdrive in hypertension: evidence, mechanisms and clinical implications.

Current Hypertension Reports
Guido GrassiG Mancia

Abstract

In hypertensive patients the risk of developing cardiovascular events and complications depends not only on the magnitude of the blood pressure elevation, but also, and to a consistent extent, on the presence of associated cardiovascular risk factors, concomitant disease and target organ damage. Recent findings suggest that also sympathetic overdrive and alterations in blood pressure variability (which are detected in hypertension) may participate at the increased cardiovascular risk of the patients with high blood pressure. This review will discuss the evidence collected over the past few years on the relationships between sympathetic activation and blood pressure variability and their impact on cardiovascular risk profile.

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Citations

Apr 16, 2013·Current Hypertension Reports·Guido GrassiGiuseppe Mancia
May 9, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mohammed F FaramawiSaly Abouelenien
Dec 23, 2015·Biochemical and Biophysical Research Communications·Viswanathan SaraswathiAlexander V Kabanov
Aug 28, 2014·Brain and Behavior·Valeri D GoncharukDick F Swaab
Mar 24, 2016·Current Hypertension Reports·Maria-Cláudia IrigoyenFernanda Marciano Consolim-Colombo
Oct 11, 2015·Australasian Physical & Engineering Sciences in Medicine·Lin XuWenhua Huang
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Sep 17, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keisuke ShinoharaHiroyuki Tsutsui

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