PMID: 2109936Apr 1, 1990Paper

Total CO2 transport in rat cortical collecting duct in chloride-depletion alkalosis

The American Journal of Physiology
J D GiffordJ H Galla

Abstract

Previous studies in chloride-depletion metabolic alkalosis (CDA) generated by intraperitoneal dialysis have suggested major alterations in chloride and bicarbonate transport beyond the distal convoluted tubule. To investigate the possible role of the cortical collecting duct (CCD) in the pathophysiology of CDA, isolated CCD segments were perfused in vitro from either control (CON) rats dialyzed against Ringer-bicarbonate or those made alkalotic by peritoneal dialysis with 0.15 M NaHCO3. Tubules from CDA animals secreted CO2 for greater than or equal to 3 h after dissection (-22.4 +/- 7.2 pmol.mm-1.min-1) compared with CON tubules that absorbed CO2 (18.3 +/- 4.2 pmol.mm-1.min-1). Replacement of luminal chloride with gluconate in the perfusate abolished net total CO2 (tCO2) secretion in tubules from CDA animals (from -21.5 +/- 4.5 to -2.7 +/- 2.3 pmol.mm-1.min-1) but did not alter net tCO2 absorption in tubules from CON animals. In contrast, removal of bath chloride increased net tCO2 secretion (-12.1 +/- 2.9 to -26.1 +/- 3.6 pmol.mm-1.min-1) in CDA tubules, whereas net tCO2 flux was altered from absorption to secretion in CON tubules (15.5 +/- 4.0 to -13.6 +/- 9.2 pmol.mm-1.min-1). These results demonstrate that 1) CDA generated...Continue Reading

Citations

Apr 17, 2013·Physiological Reviews·Mark D Parker, Walter F Boron
May 16, 2001·American Journal of Physiology. Renal Physiology·A M Weinstein
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Snezana PetrovicManoocher Soleimani
Jan 31, 2003·American Journal of Physiology. Renal Physiology·Sebastian FrischeSøren Nielsen
Sep 24, 2004·Physiological Reviews·Carsten A WagnerJohn P Geibel

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