Total contact casting combined with human fibroblast-derived dermal tissue in 15 DFU patients

Journal of Wound Care
H Kashefsky, William A Marston

Abstract

To investigate the use of a cryopreserved human fibroblast-derived dermal substitute (Dermagraft; DG) in combination with total contact casting (TCC) in patients with diabetic foot ulcers, compared with previously published rates of healing with TCC alone. Fifteen consecutive diabetic foot ulcer patients were referred to a multi-speciality clinic to be managed with a combination of DG and TCC, after showing no progress toward healing following at least 4 weeks of standard, conservative therapy. Follow-up visits were scheduled every 7 days, for a period of 12 weeks, or until fully healed. At each visit, DG and TCC were applied by the investigating clinician, and ulcer size and depth were recorded. Photographs were taken once a month, or when healed. If indicated, debridement was done to remove fibrotic tissue, callus and slough. The results demonstrated an average healing rate of 23.7 ± 16.3 days. The average number of DG applications was 2.1. There was no correlation observed between ulcer duration, or ulcer location (forefoot or mid-foot), and time to healing; however, a correlation was found between wound size and healing time. The findings may suggest combining advanced healing modalities, such as DG with TCC, can be done an...Continue Reading

References

Jul 4, 1977·Advances in Experimental Medicine and Biology·G D Winter
Jul 15, 1992·Annals of Internal Medicine·G E ReiberT D Koepsell
May 1, 1990·Diabetes Care·R E PecoraroE M Burgess
Dec 15, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·V Falanga
May 26, 2001·Diabetes Care·D G ArmstrongL B Harkless
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S E GardnerB N Doebbeling
May 27, 2003·Diabetes Care·William A MarstonUNKNOWN Dermagraft Diabetic Foot Ulcer Study Group
Nov 14, 2006·Foot and Ankle Clinics·Peter R Cavanagh, Tammy M Owings
Nov 23, 2006·Current Diabetes Reports·Stephen C DavisRobert Kirsner
Aug 13, 2008·Diabetes Care·Stephanie C WuDavid G Armstrong
Jul 1, 1995·Tissue Engineering·G K NaughtonT M Grillot

❮ Previous
Next ❯

Citations

Oct 8, 2013·Expert Opinion on Biological Therapy·Robert C RennertMichael T Longaker
Jul 3, 2013·Journal of the American College of Surgeons·Rami A KamelEdward J Caterson
Jul 25, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yan WangJiao He
Sep 5, 2015·Advances in Wound Care·Robert G Frykberg, Jaminelli Banks
Sep 3, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Uazman AlamRayaz A Malik

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
A A OmarS Homer-Vanniasinkam
© 2021 Meta ULC. All rights reserved