Total coronary atherosclerotic plaque burden assessment by CT angiography for detecting obstructive coronary artery disease associated with myocardial perfusion abnormalities

Journal of Cardiovascular Computed Tomography
Satoru KishiArmin Arbab-Zadeh

Abstract

Total atherosclerotic plaque burden assessment by CT angiography (CTA) is a promising tool for diagnosis and prognosis of coronary artery disease (CAD) but its validation is restricted to small clinical studies. We tested the feasibility of semi-automatically derived coronary atheroma burden assessment for identifying patients with hemodynamically significant CAD in a large cohort of patients with heterogenous characteristics. This study focused on the CTA component of the CORE320 study population. A semi-automated contour detection algorithm quantified total coronary atheroma volume defined as the difference between vessel and lumen volume. Percent atheroma volume (PAV = [total atheroma volume/total vessel volume] × 100) was the primary metric for assessment (n = 374). The area under the receiver operating characteristic curve (AUC) determined the diagnostic accuracy for identifying patients with hemodynamically significant CAD defined as ≥50% stenosis by quantitative coronary angiography and associated myocardial perfusion abnormality by SPECT. Of 374 patients, 139 (37%) had hemodynamically significant CAD. The AUC for PAV was 0.78 (95% confidence interval [CI] 0.73-0.83) compared with 0.84 [0.79-0.88] by standard expert CTA ...Continue Reading

References

Aug 15, 2009·JACC. Cardiovascular Imaging·K Lance Gould
Mar 7, 2012·Circulation·Armin Arbab-ZadehValentin Fuster
Mar 21, 2012·JACC. Cardiovascular Imaging·Stella-Lida PapadopoulouPim J de Feyter
Aug 14, 2012·Circulation. Cardiovascular Imaging·Rodrigo J CerciJoao A C Lima
Aug 28, 2012·JAMA : the Journal of the American Medical Association·James K MinLaura Mauri
Apr 23, 2013·European Journal of Radiology·Christopher HerzogU Joseph Schoepf
Oct 27, 2015·Current Cardiovascular Imaging Reports·Amir Ali Rahsepar, Armin Arbab-Zadeh

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Citations

Dec 3, 2016·Journal of the American College of Cardiology·Armin Arbab-Zadeh, Valentin Fuster
Jul 6, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Axel SchmermundThomas Voigtländer
Jul 4, 2020·The International Journal of Cardiovascular Imaging·Diana OpincariuImre Benedek
Mar 8, 2021·Journal of Cardiovascular Computed Tomography·Armin Arbab-Zadeh
Aug 14, 2021·Emergency Radiology·Ahmed Abdel Khalek Abdel Razek, Dalia Fahmy

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