Total dose iron dextran infusion in cancer patients: is it SaFe2+?

Journal of the National Comprehensive Cancer Network : JNCCN
Jeffrey A GilreathGeorge M Rodgers

Abstract

The feasibility of the large, single-dose intravenous iron repletion method, which is known today as total dose infusion (TDI), has been demonstrated over decades. However, this method of iron repletion was chiefly developed for patients with large iron deficits, such as those with pregnancy-induced anemia, chronic bleeding disorders, and absolute iron-deficiency anemia (serum ferritin < 30 ng/mL, transferrin saturation < 15%) who were unable to receive frequent small doses of intravenous iron. Today, 50 years after the advent of TDI, more is known about iron metabolism and storage, but the optimal dosing strategy for intravenous iron in patients with cancer is still not well defined. The proinflammatory state of cancer, or its treatment, may influence the response to intravenous iron therapy. Additionally, the long-term adverse effects of large single doses or smaller more frequent doses have yet to be studied in the oncology population. Historically, safety concerns surrounding the administration of intravenous iron have centered on anaphylaxis. Newer concerns are being raised, such as oxidative stress, iron overload, venous thromboembolism, infection risk, and tumor growth. Therefore, with the original premise of TDI assumin...Continue Reading

Citations

Feb 18, 2014·American Journal of Hematology·Jeffrey A GilreathGeorge M Rodgers
Sep 17, 2015·Wiener klinische Wochenschrift·Heinz LudwigHartmut Link
Oct 3, 2018·Pharmaceuticals·Fabiana BustiDomenico Girelli
Jun 20, 2020·Blood·Jeffrey A Gilreath, George M Rodgers
Mar 30, 2021·Frontiers in Immunology·Aysegül AksanJürgen Stein
Jun 2, 2021·The Journal of Clinical Investigation·Navid KoleiniHossein Ardehali
Apr 11, 2019·Acta Haematologica·George M Rodgers, Jeffrey A Gilreath

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