Total enantioselectivity in the DNA binding of the dinuclear ruthenium(II) complex [[Ru(Me2bpy)2]2(mu-bpm)]4+ [bpm = 2,2'-bipyrimidine; Me2bpy = 4,4'-dimethyl-2,2'-bipyridine

Dalton Transactions : an International Journal of Inorganic Chemistry
Jayden A SmithF Richard Keene

Abstract

The binding of the three stereoisomers (DeltaDelta-, LambdaLambda- and DeltaLambda-) of the dinuclear ruthenium(II) complex [[Ru(Me2bpy)2]2(mu-bpm)]4+ [Me2bpy = 4,4'-dimethyl-2,2'-bipyridine; bpm = 2,2'-bipyrimidine] to a tridecanucleotide containing a single adenine bulge has been studied by 1H NMR spectroscopy. The addition of the DeltaDelta-isomer to d(CCGAGAATTCCGG)2 induced significant chemical shift changes for the base and sugar resonances of the residues at the bulge site (G3A4G5/C11C10), whereas small shifts were observed upon addition of the enantiomeric LambdaLambda-form. NOESY spectra of the tridecanucleotide bound with the DeltaDelta-isomer revealed intermolecular NOE's between the metal complex and the nucleotide residues at the bulge site, while only weak NOE's were observed to terminal residues to the LambdaLambda-form. Competitive binding studies were performed where both enantiomers were simultaneously added to the tridecanucleotide, and for all ratios of the two stereoisomers the DeltaDelta-isomer remained selectively bound at the bulge site with the LambdaLambda-enantiomer localised at the terminal regions of the tridecanucleotide. The meso-diastereoisomer (DeltaLambda) was found to bind to the tridecanucleo...Continue Reading

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Citations

Jun 17, 2006·Chemical Communications : Chem Comm·Jayden A Smith, F Richard Keene
Apr 11, 2008·Chemical Communications : Chem Comm·Veronica GonzalezJoe Otsuki
Jul 28, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Jaroslav MalinaViktor Brabec
Nov 28, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Benjamin J PagesJanice R Aldrich-Wright
Jun 29, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Joy L MorganF Richard Keene
Oct 19, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Johannes G Vos, John M Kelly
May 9, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Caitriona B SpillaneF Richard Keene
Sep 26, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Joy L MorganF Richard Keene
Feb 15, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Caitriona B SpillaneF Richard Keene
Jul 18, 2008·Molecular BioSystems·Damian P BuckF Richard Keene
Oct 31, 2008·Chemistry : a European Journal·Christopher R K GlassonCherie Motti
Jun 21, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Caitriona B SpillaneF Richard Keene
Jun 28, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Jayden A SmithF Richard Keene
Jun 30, 2009·DNA and Cell Biology·Li-Feng TanXiLing Liang
Mar 2, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Xiao-Long ZhaoKe-Zhi Wang
Feb 16, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·F Richard Keene
Oct 8, 2020·Chemistry : a European Journal·Ondrej HrabinaViktor Brabec
Sep 14, 2006·Chemical Reviews·Michael Kruppa, Burkhard König

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