Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures

BMC Public Health
Andrew W BergenBarbara Zedler

Abstract

The Total Exposure Study was a stratified, multi-center, cross-sectional study designed to estimate levels of biomarkers of tobacco-specific and non-specific exposure and of potential harm in U.S. adult current cigarette smokers (≥one manufactured cigarette per day over the last year) and tobacco product non-users (no smoking or use of any nicotine containing products over the last 5 years). The study was designed and sponsored by a tobacco company and implemented by contract research organizations in 2002-2003. Multiple analyses of smoking behavior, demographics, and biomarkers were performed. Study data and banked biospecimens were transferred from the sponsor to the Virginia Tobacco and Health Research Repository in 2010, and then to SRI International in 2012, for independent analysis and dissemination. We analyzed biomarker distributions overall, and by biospecimen availability, for comparison with existing studies, and to evaluate generalizability to the entire sample. We calculated genome-wide statistical power for a priori hypotheses. We performed clinical chemistries, nucleic acid extractions and genotyping, and report correlation and quality control metrics. Vital signs, clinical chemistries, and laboratory measures of...Continue Reading

References

Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Jul 1, 1980·Archives of Environmental Health·R BosséJ W Rowe
Jul 21, 1998·JAMA : the Journal of the American Medical Association·E J Pérez-StableN L Benowitz
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A CarfrayG L Warwick
Jan 25, 2003·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Geraldine M McQuillanRaynard Kington
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brett G MasayesvaJoseph Califano
Jun 9, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·B K ZedlerA R Tricker
Feb 3, 2009·Handbook of Experimental Pharmacology·Neal L BenowitzPeyton Jacob
Feb 19, 2009·Biochemical and Biophysical Research Communications·Luisa AiroldiRoberto Fanelli
Jun 2, 2009·Regulatory Toxicology and Pharmacology : RTP·Paul MendesHans J Roethig
Aug 25, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hans J RoethigPaul E Mendes
Dec 23, 2009·Regulatory Toxicology and Pharmacology : RTP·Jingzhu WangPaul Mendes
Mar 17, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·David J Lee, Antoine Messiah
Apr 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ram B Jain, John T Bernert
Dec 29, 2010·Journal of Proteome Research·James D BortnerKaram El-Bayoumy
Feb 19, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kimberly Frost-PinedaMohamadi Sarkar
Feb 24, 2011·Regulatory Toxicology and Pharmacology : RTP·Raheema S Muhammad-KahMohamadi Sarkar
Apr 19, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kaisu Keskitalo-VuokkoJaakko Kaprio
May 13, 2011·American Journal of Respiratory and Critical Care Medicine·David Van SickleJohn Mullahy
Jun 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jianmin LiuMohamadi Sarkar
Jul 30, 2011·Regulatory Toxicology and Pharmacology : RTP·Raheema Muhammad-KahMohamadi Sarkar
Aug 25, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Maria N TimofeevaPaul Brennan
Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ajna HamidovicEric Jorgenson
Apr 27, 2012·Journal of the National Cancer Institute·Marcus R MunafòGeorge Davey Smith
Jun 8, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Stephen M Rappaport
Sep 11, 2012·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 24, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brian Rostron
Dec 18, 2012·Journal of Proteome Research·Ping-Ching HsuPeter G Shields
May 22, 2013·PloS One·Sonja ZeilingerThomas Illig
Apr 18, 2014·Journal of Addictive Diseases·Kimberly Frost-PinedaQiwei Liang

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

Quanto
STATA SE
SAS

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Stephen S HechtDorothy K Hatsukami
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
N L BenowitzP Jacob
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Nisha D AlmeidaMichael S Kramer
JAMA : the Journal of the American Medical Association
R D Barlow, N J Wald
© 2021 Meta ULC. All rights reserved