Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4

Oxidative Medicine and Cellular Longevity
Ping ZhaoJian Gao

Abstract

Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Researches have confirmed that oxidative stress which is regulated by NADPH oxidase-4 (NOX4), a main source of reactive oxygen species (ROS), is an important molecular mechanism underlying PF. Previous studies showed that total glucosides of Danggui Buxue Tang (DBTG), an extract from a classical traditional Chinese herbal formula, Danggui Buxue Tang (DBT), attenuated bleomycin-induced PF in rats. However, the mechanisms of DBTG are still not clear. We hypothesize that DBTG attenuates PF through regulating the level of oxidative stress by inhibiting NOX4. And we found that fibrosis indexes hydroxyproline (HYP) and type I collagen (Col-I) were lower in DBTG groups compared with the model group. In addition, the expression of transforming growth factor-β1 (TGF-β1) and expression of alpha smooth muscle actin (α-SMA) were also much more decreased than the model group. For oxidative stress indicators, DBTG blunted the decrease of superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC), and the increase in malondialdehyde (MDA), 8-iso-prostaglandin in lung homogenates. Treatment with DBTG restrained the expression of NOX4 compared to t...Continue Reading

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Citations

Sep 14, 2017·Journal of Cellular Biochemistry·Mahesh M GoudaYashodhar P Bhandary
Oct 30, 2018·Journal of Cellular Physiology·Jiao QuJian Gao
Feb 26, 2019·The Journal of Pharmacology and Experimental Therapeutics·Robbie L McLeodSanjiv Shah
Feb 6, 2020·Experimental and Therapeutic Medicine·Yuting PanHuifang Cao
Feb 7, 2021·BioFactors·Seyede Atefe HosseiniAmirhossein Sahebkar
Feb 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chengyin LiBin Wu
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guowei GongZhen Wen
May 11, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qunfang YangXiaohong Chen

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Methods Mentioned

BETA
ELISA
MDA

Software Mentioned

SPSS
Graphpad prism

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