Abstract
Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Researches have confirmed that oxidative stress which is regulated by NADPH oxidase-4 (NOX4), a main source of reactive oxygen species (ROS), is an important molecular mechanism underlying PF. Previous studies showed that total glucosides of Danggui Buxue Tang (DBTG), an extract from a classical traditional Chinese herbal formula, Danggui Buxue Tang (DBT), attenuated bleomycin-induced PF in rats. However, the mechanisms of DBTG are still not clear. We hypothesize that DBTG attenuates PF through regulating the level of oxidative stress by inhibiting NOX4. And we found that fibrosis indexes hydroxyproline (HYP) and type I collagen (Col-I) were lower in DBTG groups compared with the model group. In addition, the expression of transforming growth factor-β1 (TGF-β1) and expression of alpha smooth muscle actin (α-SMA) were also much more decreased than the model group. For oxidative stress indicators, DBTG blunted the decrease of superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC), and the increase in malondialdehyde (MDA), 8-iso-prostaglandin in lung homogenates. Treatment with DBTG restrained the expression of NOX4 compared to t...Continue Reading
References
Dec 13, 2006·Rapid Communications in Mass Spectrometry : RCM·Ping WangZhibiao Yi
Jan 8, 2008·Antioxidants & Redox Signaling·Vuokko L Kinnula, Marjukka Myllärniemi
Apr 10, 2009·Current Medicinal Chemistry·M Gharaee-KermaniM R Gyetko
Aug 25, 2009·Nature Medicine·Louise HeckerVictor J Thannickal
Oct 24, 2009·American Journal of Respiratory and Critical Care Medicine·Thomas H SissonRichard H Simon
May 11, 2010·Free Radical Biology & Medicine·Corrine R Kliment, Tim D Oury
Mar 23, 2011·Journal of Ethnopharmacology·Jian GaoXu Shao
Apr 26, 2011·The International Journal of Biochemistry & Cell Biology·Ye CuiJack Gauldie
Jun 24, 2011·Thorax·Zhe Hui Hoo, Moira K B Whyte
Oct 25, 2011·Molecular Aspects of Medicine·Brooks M HybertsonJoe M McCord
May 11, 2012·The Journal of Pharmacy and Pharmacology·Jian GaoQiang Wu
Jul 25, 2012·Fibrogenesis & Tissue Repair·Nevins W ToddSergei P Atamas
Oct 12, 2012·Drug Design, Development and Therapy·Huzaifa I Adamali, Toby M Maher
Dec 4, 2012·European Respiratory Review : an Official Journal of the European Respiratory Society·Luba NalysnykDirk Esser
Dec 12, 2012·Biochimica Et Biophysica Acta·Paul ChereshDavid W Kamp
Aug 28, 2013·American Journal of Respiratory Cell and Molecular Biology·Elizabeth R JarmanGabor Jarai
Apr 11, 2014·Science Translational Medicine·Louise HeckerVictor J Thannickal
Dec 6, 2014·Current Rheumatology Reports·Sonsoles Piera-Velazquez, Sergio A Jimenez
Mar 23, 2015·Journal of Ethnopharmacology·Amy Guo-wei GongKarl Wah-keung Tsim
Apr 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Wen FangShu-Ju Wu
Citations
Dec 17, 2016·Scientific Reports·Wencheng ZhouJian Gao
Sep 14, 2017·Journal of Cellular Biochemistry·Mahesh M GoudaYashodhar P Bhandary
Mar 16, 2018·Bioscience Reports·Huisheng WuYanlin Wang
Oct 30, 2018·Journal of Cellular Physiology·Jiao QuJian Gao
Feb 26, 2019·The Journal of Pharmacology and Experimental Therapeutics·Robbie L McLeodSanjiv Shah
Feb 6, 2020·Experimental and Therapeutic Medicine·Yuting PanHuifang Cao
Nov 22, 2017·BioMed Research International·Yangping CaiMiao Jiang
Aug 2, 2017·Oxidative Medicine and Cellular Longevity·Chaoliang TangZhongyuan Xia
May 7, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Panfeng XuJianying Zhou
Sep 21, 2018·Nutrients·Chih-Wei ChangMei-Chich Hsu
Nov 30, 2019·Journal of Oncology·Tsung-Han WuChang-Jer Wu
May 20, 2020·Frontiers in Pharmacology·Yufeng ZhangMengshu Cao
Jun 28, 2018·Frontiers in Pharmacology·Yunping BaiTiqiang Zhou
Feb 7, 2021·BioFactors·Seyede Atefe HosseiniAmirhossein Sahebkar
Feb 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chengyin LiBin Wu
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guowei GongZhen Wen
May 11, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qunfang YangXiaohong Chen