Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats.

Journal of Ethnopharmacology
Le KangYa-Gang Song

Abstract

Herbaceous peony (Paeonia lactiflora Pall.) flower has been used widely in dietotherapy in China and other countries. It has good ethnopharmacological value in the treatment of various metabolic diseases. However, the molecular mechanisms by which it lowers serum uric acid are unknown. The development of pharmaceutical resources is very important. Here, we sought to elucidate the mode of action of herbaceous peony in terms of reducing uric acid levels. In the present research, the effects of the total glucosides of herbaceous peony flower were investigated in a rat hyperuricaemia model. Another aim of the study was to clarify the mechanism by which herbaceous peony flower (TGPF) lowers serum uric acid levels. A hyperuricaemic rat model was induced via intragastric administration of 100 mg/kg adenine and 250 mg/kg ethambutol hydrochloride (EH) for 23 d. Then TongFengShu 600 mg/kg, allopurinol 42 mg/kg, or TGPF (50 mg/kg, 100 mg/kg, or 200 mg/kg) was administered 1 h after the adenine and EH treatments. TGPF improved weight loss and decreased serum UA, XOD, MCP-1, TNF-α, Cr, and BUN in the rats with hyperuricaemic nephropathy. TGPF downregulated renal URAT1 and GLUT9, upregulated renal OAT1, and ameliorated histopathological chan...Continue Reading

References

Sep 18, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jing SuJi-Jia Shen
Dec 17, 2014·Environment International·Chin-Chi KuoAna Navas-Acien
Oct 30, 2016·Critical Reviews in Food Science and Nutrition·Ilaria PelusoMaura Palmery
Dec 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huifang ZhangRuixue Deng
Mar 5, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Minxia PangGuiyuan Lv
May 1, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ana Beatriz Vargas-Santos, Tuhina Neogi
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuanli ZhouJiping Liu
Aug 15, 2018·Pflügers Archiv : European journal of physiology·Muriel AubersonOlivier Bonny
Nov 2, 2018·Journal of Nephrology·Ze WangChangxiao Liu
Nov 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuusuke TashiroToshiaki Makino
Feb 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mengyi ShenLi Yang

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