Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zhongfang ZhaoHong-wei Liu

Abstract

Mesenchymal stem cells (MSCs) have been used clinically and experimentally to relieve severe immune-related diseases due to their immunomodulatory properties, but these are impaired by inflammation. Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease. In the present study, we found MSCs from OLP with higher expression of interleukin (IL)-6, tumour necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β) and IL-10 compared with control. Total glucosides of paeony (TGP) significantly improves the immunomodulatory function of MSCs by inhibiting IL-6 and TNF-α expression and increasing TGF-β and IL-10 expression. Moreover, TGP can downregulate p-STAT3 expression through upregulation of miR-124. The changes of IL-6, TGF-β and p-STAT3 were further confirmed by overexpression and knockdown of miR-124 in MSCs. Taken together, the immune-regulating function of MSCs can be improved by TGP via the miR-124/STAT3 pathway.

References

Nov 5, 2005·Oral Diseases·D EisenK Thongprasom
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muriel SudresJosé L Cohen
Apr 18, 2009·Basic & Clinical Pharmacology & Toxicology·Wang-Lin JiangFeng-Hua Fu
Nov 26, 2010·Otolaryngologic Clinics of North America·Pallavi Parashar
Mar 13, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ming ZhaoQian-jin Lu
May 16, 2012·Annals of the Rheumatic Diseases·Anastasia PapadopoulouEvangelia Yannaki
Jun 12, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Sanxiang XieShengrong Zhu
Jan 9, 2014·Journal of Translational Medicine·Mahmood S ChoudheryDavid T Harris
Sep 13, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhihui ZhangHongwei Liu
Jun 10, 2015·Rejuvenation Research·Jasmin NurkovicMiodrag Stojkovic
Mar 24, 2016·Stem Cell Research & Therapy·Emmanuel GibonStuart B Goodman
Apr 7, 2016·Journal of Cancer Prevention·Soma Susan VargheseArun George
Jun 5, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Zoya B Kurago
Oct 21, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhen QinXia Liu
Nov 24, 2016·Alimentary Pharmacology & Therapeutics·C GrégoireY Beguin
Dec 19, 2016·European Journal of Cell Biology·Sajjad SisakhtnezhadHassan Akrami
Jan 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chantal KuhnHoward L Weiner
Mar 28, 2017·Biochemical and Biophysical Research Communications·Dan WangMingdong Hu
Aug 8, 2017·Bone Marrow Transplantation·C Fernández-MaquedaJ R Cabrera-Marín
Sep 18, 2017·Complementary Therapies in Medicine·Jing LuoQing-Wen Tao
Sep 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shan HuangPing Lei
Sep 30, 2017·Experimental Biology and Medicine·Lijiao GengYong Chen
Dec 15, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qing WeiZekun Guo

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Citations

Jan 8, 2020·Cell Death & Disease·Jie DuBin Zhao
Oct 14, 2018·World Journal of Surgical Oncology·Li ZhuDihong Tang
Dec 12, 2020·Drug Development and Industrial Pharmacy·Chengying ShenXiaofang Li
Jun 13, 2020·Explore : the Journal of Science and Healing·Xin MaHui-Min Zhang
Aug 10, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Zhichao MengKuimei Wang

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