Total HIV-1 DNA Dynamics and Influencing Factors in Long-Term ART-Treated Japanese Adults: A Retrospective Longitudinal Analysis

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Kamelia R StanoevaShuzo Matsushita

Abstract

Understanding HIV persistence in treated patients is an important milestone toward drug-free control. We aimed at analyzing total HIV DNA dynamics and influencing factors in Japanese patients who received more than a decade of suppressive antiretroviral treatment (ART). A retrospective study including clinical records and 840 peripheral blood mononuclear cells samples (mean 14 samples/patient) for 59 patients (92% male) was performed. Subjects were divided into 2 groups: with and without hematological comorbidity (mainly hemophilia) plus hepatitis C virus coinfection. Total HIV DNA was measured in peripheral blood mononuclear cells by quantitative polymerase chain reaction. The dynamics, regression over time, and influence of antiretrovirals by group were estimated using a novel regression model (R software v 3.2.3). Total HIV DNA decreased on ART initiation, and subsequently, its dynamics varied between groups with previously undescribed fluctuations. If calculated by on-treatment, the mean total HIV DNA levels were similar. The comorbidity group had unstable levels showing different regression over time (P = 0.088/0.094 in year 1/after year 8 of ART) and significantly different treatment responses as shown by antiretroviral g...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M FolksA S Fauci
Dec 22, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J IzopetJ Puel
May 3, 2002·Nature·Daniel C DouekRichard A Koup
Oct 9, 2002·Journal of Virology·Una O'DohertyMichael H Malim
Feb 6, 2003·International Journal of Hematology·Shinobu TatsunamiKaneo Yamada
Aug 5, 2008·International Journal of Hematology·Shinobu TatsunamiMasashi Taki
Jun 23, 2009·Nature Medicine·Nicolas ChomontRafick-Pierre Sékaly
May 12, 2010·AIDS Research and Human Retroviruses·Milena NasiAndrea Cossarizza
Jul 5, 2011·Retrovirology·Richard D Sloan, Mark A Wainberg
Jul 21, 2012·Nature Reviews. Immunology·Steven G DeeksFrançoise Barré-Sinoussi
Mar 6, 2013·PLoS Pathogens·Susanne ErikssonJanet D Siliciano
Apr 11, 2013·PloS One·Matthew C StrainDouglas D Richman
Jun 6, 2013·PLoS Pathogens·Gregory M LairdRobert F Siliciano
Jun 19, 2013·Immunological Reviews·Nichole R KlattSteven G Deeks
Oct 25, 2013·The New England Journal of Medicine·Deborah PersaudKatherine Luzuriaga
Jul 31, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Guillaume J BessonJohn W Mellors
Aug 15, 2014·Journal of Virology·Claire VandergeetenNicolas Chomont
Sep 14, 2014·ELife·James P WilliamsUNKNOWN SPARTACTrial Investigators
Jan 31, 2015·Cell·Lillian B CohnMichel C Nussenzweig
Apr 17, 2015·The Journal of Infectious Diseases·Amanda M CrooksNancie M Archin
Apr 18, 2015·The Journal of Infectious Diseases·Kelly A Metcalf PateJoel N Blankson
Aug 14, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Priyanka UpretyDeborah Persaud
Oct 2, 2015·EBioMedicine·Francesco Andrea ProcopioNicolas Chomont
Jan 15, 2016·Journal of Clinical Microbiology·Feiyu HongJohn W Mellors

❮ Previous
Next ❯

Citations

Apr 13, 2021·The Journal of Infectious Diseases·Hiroo KatsuyaYorifumi Satou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Journal of the International Association of Providers of AIDS Care
Sithakom PhusantiSomnuek Sungkanuparph
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
A SaracinoG Angarano
© 2022 Meta ULC. All rights reserved