Total homocyst(e)ine in plasma and amniotic fluid of pregnant women

Metabolism: Clinical and Experimental
S S KangH Y Cook

Abstract

Total homocyst(e)ine was determined by the quantitation of protein-bound homocyst(e)ine in the stored plasma and amniotic fluid from 25 pregnant women and in the stored plasma from 17 nonpregnant women. The mean +/- SE of plasma total homocyst(e)ine was 29.8 +/- 2.4 nmol/g protein in pregnant women and 52.4 +/- 3.8 nmol/g protein in nonpregnant women. In contrast, the mean +/- SE of total homocyst(e)ine in amniotic fluid obtained at 16 weeks of gestation was 36.3 +/- 2.9 nmol/g protein. There was a statistically significant difference in the plasma total homocyst(e)ine concentrations from pregnant and nonpregnant women (P less than 0.01). Similarly, there was also a statistically significant difference between plasma total homocyst(e)ine from nonpregnant women and amniotic fluid total homocyst(e)ine (P less than 0.01). These observations suggested that the metabolism of homocysteine to cysteine was more efficient in pregnant women. In addition, the concentrations of total homocyst(e)ine in amniotic fluids were within narrow limits in normal pregnancies. Hence, total homocyst(e)ine concentration might be very valuable as a rapid assessment of fetuses for congenital defects of homocysteine metabolism.

References

May 1, 1986·The Journal of Clinical Investigation·S S KangJ V Messer
Apr 1, 1974·The Journal of Pediatrics·A M JohnsonG Greenspan
Apr 1, 1970·Obstetrical & Gynecological Survey·D R Ostergard
Jul 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·T L Perry, S Hansen
Jul 1, 1964·Journal of Clinical Pathology·J B GIBSOND W NEILL

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Citations

Jul 25, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A G MinkhorstP H de Wit
Mar 8, 2000·Atherosclerosis·A E HakC D Stehouwer
Mar 29, 2001·Obstetrics and Gynecology·R HietalaT Laatikainen
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J W J van WerschJ A Zandvoort
Mar 22, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M de la CalleE Cabrillo
Aug 22, 2001·Maturitas·G ChristodoulakosG Creatsas
Feb 15, 2001·European Journal of Internal Medicine·C F. EbenbichlerJ R. Patsch
Jan 10, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M R NehlerJ M Porter
Jan 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M R NehlerJ M Porter
Sep 29, 2005·European Journal of Clinical Nutrition·C H Ramlau-HansenJ Møller
Dec 3, 1999·Journal of Internal Medicine·O NygårdP M Ueland
Nov 5, 1999·Clinical and Experimental Pharmacology & Physiology·K ChowK O
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Harpal S Randeva
Nov 1, 1994·European Journal of Clinical Investigation·M J van der MoorenR Rolland
Nov 1, 1995·European Journal of Clinical Investigation·M G WoutersT K Eskes
Dec 1, 1994·Journal of Internal Medicine·M R Malinow
Jan 1, 1997·British Journal of Obstetrics and Gynaecology·R P Steegers-TheunissenT Chard
Jun 1, 2007·Biomarkers in Medicine·Michelle M Murphy
Sep 26, 2003·The Proceedings of the Nutrition Society·Valerie A Holmes
Jan 5, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R RoopnarinesinghP Mayne
Aug 8, 2007·Animal Reproduction Science·C TrisoliniR L Sciorsci
May 1, 1987·Metabolism: Clinical and Experimental·S S KangM Norusis
Mar 6, 2002·Seminars in Perinatology·George R Saade, Claire McLintock
May 1, 1995·American Journal of Obstetrics and Gynecology·R P Steegers-TheunissenT K Eskes
Feb 1, 1992·Contraception·R P Steegers-TheunissenT K Eskes
Jan 7, 2004·Journal of the Society for Gynecologic Investigation·Robert W PowersKirk P Conrad
Mar 3, 2005·Physiological Genomics·Sheila ErnestJoseph H Nadeau
Jul 28, 2004·Clinical Chemistry·Per Magne Ueland, Stein Emil Vollset
Jan 8, 2004·Clinical Chemistry·Helga RefsumJohn M Scott
Jun 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·L BrattströmB Hultberg
May 11, 2006·The American Journal of Clinical Nutrition·Tsunenobu Tamura, Mary Frances Picciano
Aug 1, 2002·Drugs & Aging·Brenna CholertonSanjay Asthana
Oct 9, 2002·Obstetrical & Gynecological Survey·Amy M Adelberg, Jeffrey A Kuller
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·G AnkerE A Lien

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