Total intravenous anesthesia vs single pharmacological prophylaxis to prevent postoperative vomiting in children: A systematic review and meta-analysis

Paediatric Anaesthesia
Maximilian S SchaeferPeter Kienbaum

Abstract

Postoperative nausea and postoperative vomiting are frequent but often missed complications after general anesthesia in pediatric patients. Because inhaled anesthetics are known to trigger postoperative vomiting, total intravenous anesthesia is often administered in high-risk children to avoid the use of inhalational anesthesia. Since inhalational anesthesia might be advantageous in some situations, the question is raised whether administration of pharmacological prophylaxis offers equal protection from postoperative vomiting compared with total intravenous anesthesia alone. The aim of this systematic review was to compare total intravenous anesthesia with single-drug pharmacological prophylaxis for the protection of postoperative vomiting in pediatric patients. We conducted a systematic review (EMBASE, MEDLINE, and CENTRAL) with meta-analysis on randomized controlled trials including patients <18 years of age undergoing general anesthesia, with one group receiving propofol-based total intravenous anesthesia and another group receiving inhalational anesthesia with single pharmacological prophylaxis. Primary outcome was the overall incidence for postoperative vomiting. Secondary outcomes included early and late postoperative vom...Continue Reading

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Citations

May 31, 2019·Journal of Cataract and Refractive Surgery·Kyle M RussellToby N Weingarten
Feb 27, 2020·Minerva anestesiologica·Andrea Gentili
Dec 11, 2019·Minerva anestesiologica·Carine ZeeniMarie T Aouad
May 30, 2020·Anesthesia and Analgesia·Tong J GanBeverly K Philip
Aug 12, 2020·Anaesthesia and Intensive Care·Alfred Wy ChuaPeter Ca Kam
Oct 28, 2020·Paediatric Drugs·Anthony L Kovac
Jan 15, 2021·Der Anaesthesist·Jan JedlickaPeter Conzen

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