Total ischemic burden in patients with coronary artery disease

Cardiovascular Drugs and Therapy
J E Deanfield

Abstract

In patients with coronary artery disease, angina pectoris provides an unreliable underestimation of disease activity and risk. Unheralded myocardial infarction and sudden death are common clinical presentations. Furthermore, objective testing, in hospital and more recently during the patient's normal daily activities, has demonstrated frequent and asymptomatic episodes of ischemia, as indicated by transient ST-segment depression. Since the underlying pathophysiologic disturbances of myocardial perfusion appear to be similar in painful and painless episodes, it seems appropriate to consider them together as the "total ischemic burden" on the myocardium. Research into this functional expression of coronary disease has indicated that active ischemia is associated with an increased risk of morbid events in all clinical subgroups of patients, including those with stable angina, unstable angina, peripheral vascular disease and following myocardial infarction. If this is confirmed in prospective trials, the assessment of total ischemic burden is likely to become part of the clinical investigation of patients with coronary disease. Clinical trials testing the efficacy of interventions will need to examine the effect on ischemic activit...Continue Reading

Citations

Mar 1, 1977·The American Journal of Cardiology·S J Schang, C J Pepine
Nov 15, 1990·The American Journal of Cardiology·P C Deedwania, E V Carbajal
Jun 1, 1989·The Journal of Clinical Investigation·J B GordonA P Selwyn
Nov 9, 1989·The New England Journal of Medicine·K E RabyA P Selwyn
Nov 21, 1985·The New England Journal of Medicine·J E MullerT Robertson
May 8, 1986·The New England Journal of Medicine·S O GottliebG Gerstenblith
Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Oct 1, 1988·The American Journal of Cardiology·D TzivoniS Stern
Jul 1, 1987·Journal of the American College of Cardiology·K NademaneeB N Singh
Oct 1, 1987·Journal of the American College of Cardiology·S O GottliebG Gerstenblith
Aug 15, 1986·The American Journal of Cardiology·P F Cohn
Jan 1, 1987·Circulation·J E MullerP H Stone
Nov 3, 1984·Lancet·J E DeanfieldA P Selwyn
Dec 1, 1984·The American Journal of Cardiology·J E DeanfieldA P Selwyn
Apr 12, 1984·The New England Journal of Medicine·J E DeanfieldK Fox
Nov 1, 1984·The New England Journal of Medicine·W B Kannel, R D Abbott
Dec 1, 1984·The American Journal of Cardiology·J E DeanfieldA P Selwyn
Nov 1, 1983·British Heart Journal·A A QuyyumiK Fox

Related Concepts

Ischemia
Coronary Artery Disease
Myocardial Infarction
Holter Electrocardiography
Angina Pectoris
Secondary Parkinson Disease
Peripheral Vascular Diseases
Sudden Death
Electrocardiographic Recorders
Coronary Heart Disease

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