Total joint arthroplasty and the risk of myocardial infarction: a general population, propensity score-matched cohort study

Arthritis & Rheumatology
Na LuYuqing Zhang

Abstract

To replicate recent findings indicating that total knee arthroplasty (TKA) or total hip arthroplasty (THA) surgery will substantially reduce the risk of serious cardiovascular events among patients with osteoarthritis. A time-stratified, propensity score-matched cohort study was conducted to assess the incidence of myocardial infarction (MI) in a UK general population. The study population included individuals ages ≥50 years who had a UK National Health Service READ code diagnosis of knee osteoarthritis (to evaluate TKA) or hip osteoarthritis (to evaluate THA) between January 2000 and December 2012. Among the patients who underwent TKA and their matched non-TKA control subjects (each n = 13,849), 306 patients and 286 control subjects developed MI during the followup. During the first postoperative month, the risk of MI was substantially increased among the TKA group compared with the non-TKA group (hazard ratio [HR] 8.75, 95% confidence interval [95% CI] 3.11-24.62), and then gradually declined during the subsequent followup. The HR for the risk of MI over the entire followup was 0.98 (95% CI 0.82-1.18). The corresponding HRs for the risk of MI in those who had undergone THA compared with the non-THA group (each n = 6,063) were...Continue Reading

References

Sep 20, 1990·The New England Journal of Medicine·W H Harris, C B Sledge
Sep 13, 1990·The New England Journal of Medicine·W H Harris, C B Sledge
Nov 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R AndersonR D Gelber
Jun 10, 2000·British Journal of Clinical Pharmacology·R LawrensonR D Farmer
Aug 9, 2003·The New England Journal of Medicine·JoAnn E MansonUNKNOWN Women's Health Initiative Investigators
May 1, 2004·The Journal of Bone and Joint Surgery. American Volume·Olivier EthgenJean-Yves Reginster
Jun 16, 2004·Circulation·Luis A García RodríguezAntonio González-Pérez
Jan 15, 2005·Pharmacoepidemiology and Drug Safety·John D SeegerAlexander M Walker
Sep 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Jane BarrettJeffrey N Katz
Nov 5, 2005·Annals of the Rheumatic Diseases·J M van der WaalJ Dekker
Feb 25, 2006·The Journal of Bone and Joint Surgery. British Volume·B T BjørnaråO E Dahl
Apr 14, 2006·Basic & Clinical Pharmacology & Toxicology·Sonia Hernández-DíazLuis A García Rodríguez
Jan 4, 2007·The Journal of Bone and Joint Surgery. American Volume·Javad ParviziRichard H Rothman
May 16, 2007·Archives of Internal Medicine·Consuelo HuertaLuis A García Rodríguez
Nov 11, 2008·Journal of the American College of Cardiology·Luis Alberto García RodríguezPaola Patrignani
Aug 18, 2009·The Journal of Urology·Elisa Martín-MerinoClaus G Roehrborn
Jan 2, 2010·The Journal of Bone and Joint Surgery. British Volume·D J CullifordN K Arden
Feb 5, 2010·Pharmacoepidemiology and Drug Safety·Ana RuigómezLuis Alberto García Rodríguez
Nov 16, 2010·The British Journal of Dermatology·N M SeminaraJ M Gelfand
May 19, 2011·Circulation. Cardiovascular Quality and Outcomes·Urania Dafni
Oct 25, 2011·Annals of the Rheumatic Diseases·Jasvinder A SinghDavid G Lewallen
Jun 13, 2012·Archives of Internal Medicine·Iskandar IdrisRichard Donnelly
Jul 31, 2012·Archives of Orthopaedic and Trauma Surgery·O BruyèreJ-Y Reginster
Sep 27, 2012·JAMA : the Journal of the American Medical Association·Peter CramBrian R Wolf

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Citations

Apr 10, 2016·Arthritis & Rheumatology·Yuqing Zhang, Jingbo Niu
Aug 3, 2016·The Journal of Arthroplasty·Chirag K ShahCalin S Moucha
Jan 11, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Michael NurmohamedPaola Accossato
Oct 11, 2017·Annals of the Rheumatic Diseases·Tuhina NeogiYuqing Zhang
Oct 7, 2017·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Michael K UrbanSteven K Magid
Jan 13, 2019·Journal of Orthopaedic Surgery and Research·Yassin ElsiwyHayley Letson
Feb 6, 2018·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Anne R BassBrian F Gage
Jan 6, 2017·Clinical Orthopaedics and Related Research·Daniel D BohlJonathan N Grauer
Jun 24, 2017·Clinical Orthopaedics and Related Research·Pål O BorgenOlav Reikerås
Feb 9, 2017·Stem Cells Translational Medicine·Paul S Knoepfler
Nov 11, 2020·Journal of Orthopaedic Surgery and Research·Yassin ElsiwyHayley Letson
Jul 20, 2021·Iranian Journal of Nursing and Midwifery Research·Roya HamediZahra Atrkar-Roushan

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