Total laparoscopic hysterectomy versus abdominal hysterectomy in the treatment of patients with early stage endometrial cancer: a randomized multi center study.

BMC Cancer
Claudia B BijenMarian J E Mourits

Abstract

Traditionally standard treatment for patients with early stage endometrial cancer (EC) is total abdominal hysterectomy and bilateral salpingo oophorectomy (TAH+BSO) with or without lymph node dissection through a vertical midline incision. While TAH is an accepted effective treatment, it is highly invasive, visibly scarring and associated with morbidity. An alternative treatment is the same operation by laparoscopy. Though in several studies total laparoscopic hysterectomy (TLH+ BSO) seems a safe and feasible alternative approach in early stage endometrial cancer patients, there are no randomized data available yet. Furthermore, a randomized controlled trial with surgeons trained in laparoscopy is warranted in order to implement this technique in a safe manner. The aim of this study is to compare the treatment related morbidity, cost-effectiveness and quality of life in early stage endometrial cancer patients treated by laparoscopy versus the standard open approach. A multi centre randomized clinical phase 3 trial, including 5 university hospitals and 15 regional hospitals in the Netherlands. Only gynecologists trained in performing a TLH are allowed to participate. Patients with a clinical stage I endometrioid adenocarcinoma o...Continue Reading

References

Jun 1, 1996·American Journal of Obstetrics and Gynecology·N M SpirtosS C Ballon
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·M A LumsdenJ J Walker
Feb 1, 2002·The Journal of the American Association of Gynecologic Laparoscopists·Tom P Manolitsas, Anthony J McCartney
Feb 28, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K M Fram
Feb 27, 2004·Gynecologic Oncology·Andreas ObermairAnthony J McCartney
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A ObermairA J McCartney
May 21, 2005·Journal of Minimally Invasive Gynecology·Roberto TozziAchim Schneider

❮ Previous
Next ❯

Citations

Mar 24, 2010·Archives of Gynecology and Obstetrics·Florian MuellerU Ulrich
Apr 24, 2010·Archives of Gynecology and Obstetrics·M Sami Walid, Richard L Heaton
Jul 20, 2010·The Lancet Oncology·Marian J E MouritsGeertruida H de Bock
Mar 20, 2013·Journal of Minimally Invasive Gynecology·Hongying HeHua Zhong
Oct 20, 2010·Journal of Minimally Invasive Gynecology·Justine M BriëtHenriette J G Arts
Oct 13, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·P CapmasF Lécuru
Mar 27, 2015·Asian Journal of Endoscopic Surgery·Samsad JahanReefat Nayer
Mar 19, 2013·The Journal of Obstetrics and Gynaecology Research·Pieter J van EmpelFedde Scheele
Oct 4, 2015·American Journal of Obstetrics and Gynecology·Michael S GuySaketh R Guntupalli
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hui-Ling WangKai-Hua Zhai
Jun 4, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claudia B M BijenMarian J E Mourits
Jan 11, 2011·Gynecologic Oncology·Claudia B BijenGeertruida H de Bock
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Khadra GalaalAlberto D Lopes
Nov 1, 2018·The Cochrane Database of Systematic Reviews·Khadra GalaalAlberto D Lopes
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Anne LethabyRaj Naik
Apr 25, 2020·Annals of Surgical Oncology·Alessia AloisiMario M Leitao
May 1, 2021·International Journal of Environmental Research and Public Health·Laura Martínez-CayuelasLuis Gómez-Pérez

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy
dissection

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.