Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance, Cortical Atrophy, and Network Measures in a Memory Clinic Population

Journal of Alzheimer's Disease : JAD
Gargi BanerjeeDavid J Werring

Abstract

Recent evidence suggests that combining individual imaging markers of cerebral small vessel disease (SVD) may more accurately reflect its overall burden and better correlate with clinical measures. We wished to establish the clinical relevance of the total SVD score in a memory clinic population by investigating the association with SVD score and cognitive performance, cortical atrophy, and structural network measures, after adjusting for amyloid-β burden. We included 243 patients with amnestic mild cognitive impairment (MCI), Alzheimer's disease dementia, subcortical vascular MCI, or subcortical vascular dementia. All underwent MR and [11C] PiB-PET scanning and had standardized cognitive testing. Multiple linear regression was used to evaluate the relationships between SVD score and cognition, cortical thickness, and structural network measures. Path analyses were performed to evaluate whether network disruption mediates the effects of SVD score on cortical thickness and cognition. Total SVD score was associated with the performance of frontal (β - 4.31, SE 2.09, p = 0.040) and visuospatial (β - 0.95, SE 0.44, p = 0.032) tasks, and with reduced cortical thickness in widespread brain regions. Total SVD score was negatively corr...Continue Reading

References

Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Aug 29, 2000·Journal of Neural Transmission. Supplementum·T ErkinjunttiD W Desmond
Feb 15, 2003·IEEE Transactions on Medical Imaging·Alex P ZijdenbosAlan C Evans
Feb 22, 2003·NeuroImage·Moo K ChungAlan C Evans
Sep 29, 2004·Medical Image Analysis·Steven RobbinsSue Whitesides
Oct 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·A M J MaclullichI J Deary
Nov 22, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sang Won SeoDuk L Na
Jan 24, 2009·Lancet Neurology·Steven M GreenbergUNKNOWN Microbleed Study Group
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Feb 18, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sang Won SeoDuk L Na
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jan 9, 2010·Stroke; a Journal of Cerebral Circulation·Fergus N DoubalJoanna M Wardlaw
Mar 7, 2013·Archives of Gerontology and Geriatrics·Min-Jeong KimDuk L Na
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Sep 5, 2014·Nature Reviews. Neuroscience·Cornelis J Stam
Nov 7, 2014·Journal of Alzheimer's Disease : JAD·Hee Jin KimSang Won Seo
Mar 5, 2015·NeuroImage. Clinical·Anil M TuladharFrank-Erik de Leeuw
Jun 13, 2015·Neurology·Robert D Stevens, Yousef Hannawi
Jul 21, 2015·Neurobiology of Aging·Julie StaalsJoanna M Wardlaw
Oct 9, 2015·NeuroImage. Clinical·Christian LambertHugh S Markus
Dec 22, 2015·Biochimica Et Biophysica Acta·Gargi BanerjeeDavid J Werring
Feb 19, 2016·Neurology·Anil M TuladharFrank-Erik de Leeuw
Mar 1, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ayan K DeyBrian Levine
Mar 5, 2016·Brain : a Journal of Neurology·Christian LambertHugh S Markus
May 27, 2017·International Journal of Geriatric Psychiatry·Victor J Del BruttoJosé Biller
Sep 15, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Caroline Mj LoosJoanna M Wardlaw

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Citations

Sep 13, 2019·Stroke; a Journal of Cerebral Circulation·Owen A WilliamsRebecca A Charlton
Jul 25, 2019·Stroke and Vascular Neurology·Jing Du, Qun Xu
Dec 24, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Weiyi ZengZhanjun Zhang
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Rianne A A de HeusJurgen A H R Claassen
Oct 7, 2018·Journal of Neurology·Xiaodong ChenZhengqi Lu
Jul 30, 2018·Journal of Alzheimer's Disease : JAD·Yeshin KimSang Won Seo
Jun 4, 2020·Diagnostics·Larisa A DobryninaMarina V Krotenkova
Jul 23, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rutger HeinenUNKNOWN TRACE‐VCI study group
Jan 9, 2021·Human Brain Mapping·Yanpeng LiuJia-Hong Gao
Jan 16, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L A DobryninaM V Krotenkova
Feb 4, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Saima HilalJuan Helen Zhou
Jan 12, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Naoki SajiTakashi Sakurai
Feb 11, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lauren E OberlinFaith M Gunning
Aug 26, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kemeng ZhangMin Lou
Oct 9, 2021·AJNR. American Journal of Neuroradiology·A MahammediA Vagal
Jan 11, 2022·Stroke; a Journal of Cerebral Circulation·Prashanthi VemuriMarco Duering

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