PMID: 11343824May 10, 2001Paper

Total neuronal numbers of rat lumbosacral primary afferent neurons do not change with age

Neuroscience Letters
H A Mohammed, R M Santer

Abstract

Total cell numbers and neuronal diameters of L6 and S1 dorsal root ganglia, which provide a sensory innervation to pelvic viscera were determined in young adult (3-months-old) and compared to those in old (24-months-old) male rats. Two methods of cell counting, serial (section) reconstructions and total profile counting, were used in this study. Our data showed that the total number of L6 and S1 dorsal root ganglia (DRG) cells and their diameters remain essentially constant from 3 to 24 months of age. These results have shown that rat DRG cell numbers do not change during adult life and that neurogenesis of DRG cells in adult rats or neuronal cell death in aged rats cannot be supported. These findings are also consistent with other data supporting the maintenance of pelvic sensory innervation in old age.

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Citations

Mar 25, 2011·Brain Structure & Function·Ennio Pannese
Jul 31, 2003·Brain Research. Developmental Brain Research·Paul B Farel
Oct 24, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Stefano GeunaGuido Filogamo
Mar 21, 2007·Archives of Histology and Cytology·Huibing TanMasaru Kawabuchi
May 30, 2009·Cell Transplantation·Rabindra P SinghFeng C Zhou
Apr 30, 2013·Experimental Gerontology·Maja Marinović GuićIvica Grković
Aug 19, 2009·Annals of the New York Academy of Sciences·Shuying Wang, Kathryn M Albers
May 25, 2011·Brain Research Bulletin·Katarzyna KotulskaJacqueline London
Aug 15, 2009·Autonomic Neuroscience : Basic & Clinical·P R Brumovsky, G F Gebhart
Dec 16, 2005·Neurological Research·Katarzyna KotulskaJoanna Lewin-Kowalik
Jul 13, 2002·The Journal of Comparative Neurology·Paul B Farel
Jun 14, 2019·Frontiers in Molecular Neuroscience·Vanessa CastelliMichele d'Angelo
Jan 8, 2021·Cell and Tissue Research·Sandra C KochVolker Hartenstein

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