Total number and size distribution of motor neurons in the spinal cord of normal and EMC-virus infected mice--a stereological study

Journal of Anatomy
U J WeberB Pakkenberg

Abstract

The encephalomyocarditis virus of the diabetogenic M-strain (EMC-M) is known to cause diabetes in mice. The EMC-M virus has also been shown to cause paresis in some of the infected animals. The clinical features include an acute ascending predominantly motor paralysis, developing within days. This resembles acute idiopathic polyneuritis. The alpha motor neurons would be a possible target for the virus, so two parameters, the total number and the size distribution of motor neurons, were therefore selected for further investigation in 6 mice with neurological involvement and compared with 6 control mice. The optical fractionator method was applied for estimating the total number of motor neurons and the 3D size distribution was estimated using the rotator method in a vertical design. No difference was found in the total number of motor neurons and the size distributions were similar in the 2 groups. This design can be used as a model for the estimation of the total number of motor neurons and their size distribution in other experimental animal models.

References

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Oct 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenB Pakkenberg
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Citations

Oct 7, 2008·Brain : a Journal of Neurology·Claudia PitzerArmin Schneider
Feb 1, 2013·Journal of Virology·Jingshan ZhangHarel Dahari
Jun 12, 2020·Anatomia, histologia, embryologia·Javad SadeghinezhadMargherita De Silva
Mar 26, 2021·Journal of Anatomy·Margherita De SilvaAnnamaria Grandis
Jun 18, 2021·Anatomia, histologia, embryologia·Javad Sadeghinezhad, Jens Randel Nyengaard

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