Total pancreatectomy combined with partial pancreas autotransplantation for recurrent pancreatic cancer: a case report

Transplantation Proceedings
T KobayashiK Hatakeyama

Abstract

We describe a patient presenting with a resectable carcinoma of the remnant pancreas at 3 years after undergoing a pylorus-preserving pancreaticoduodenectomy for invasive ductal carcinoma of the pancreatic head. We also performed a distal pancreas autotransplantation using a part of the resected pancreas to preserve endocrine function. Final histologic findings showed the second tumor to be an invasive ductal carcinoma consisting of a well-differentiated tubular adenocarcinoma with similar histopathologic findings as the first tumor. There were no microscopic lymph node metastases and no evidence of microvascular invasion (pStage IA [pT1, pN0, M0] and R0 according to the International Union Against Cancer TNM classification). The patient was discharged at 20 days after surgery without any trouble and followed by adjuvant chemotherapy with S-1. The carbohydrate antigen 19-9 value was again normalized after the second surgery. Twenty months after the second operation, the patient is alive without cancer recurrence. The pancreas graft is functioning with a blood glucose of 108 mg/dL, HbA1C of 6.2%, and serum C-peptide of 1.4 ng/mL.

References

Jul 13, 2002·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
Feb 8, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Susumu TakamatsuShigeki Arii

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Citations

Aug 27, 2013·Surgery Today·Daisuke HashimotoHideo Baba
Jun 12, 2014·Current Diabetes Reports·Gianpaolo Balzano, Lorenzo Piemonti
Oct 9, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yanming ZhouYumin Li
Nov 22, 2017·Journal of Gastrointestinal Cancer·Omid SavariPiotr Witkowski
Jun 12, 2013·Annals of Surgery·Gianpaolo BalzanoLorenzo Piemonti
Aug 25, 2017·World Journal of Surgical Oncology·Shigeru FujisakiTadatoshi Takayama

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