Total pancreatectomy for pancreatic ductal adenocarcinoma: review of the National Cancer Data Base

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
W Cory JohnstonRonald F Wolf

Abstract

Total pancreatectomy is infrequently performed for pancreatic cancer. Perceived operative mortality and questionable survival benefit deter many surgeons. Clinical outcomes, described in single-center series, remain largely unknown. The National Cancer Database was queried for cases of pancreatic ductal adenocarcinoma undergoing total pancreatectomy (1998-2011). Univariate survival analyses were performed for 21 variables: demographic (8), tumor characteristics (5), surgery outcomes (6), and adjuvant therapy (2). The Log-rank test of differences in Kaplan-Meier survival curves was used for categorical variables. Variables with p < 0.05 were included in a multivariate analysis. Cox proportional hazards regression was used to analyze continuous variables and multivariate models. 2582 patients with staging and survival data made up the study population. 30-day mortality was 5.5%. Median overall survival was 15 months, with 1, 3, and 5-year survival rates of 60%, 22%, and 13%, respectively. Age, facility type, tumor size and grade, lymph node positivity, margin positivity, and adjuvant therapy significantly impacted survival in multivariate analysis. Although total pancreatectomy is a reasonable option for selected patients with pa...Continue Reading

References

Mar 1, 1996·World Journal of Surgery·I Ihse Andrén-Sandberg
Jan 13, 2001·Archives of Surgery·H M KarpoffK C Conlon
Nov 29, 2007·Annals of Surgery·Michael W MüllerMarkus W Büchler
Sep 8, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Purvi ParikhHenry A Pitt
Jun 3, 2011·The New England Journal of Medicine·Jonathan F FinksJohn D Birkmeyer
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Louise BarbierAlain Sauvanet

❮ Previous
Next ❯

Citations

May 18, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Daisuke HashimotoHideo Baba
Jul 16, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Riccardo CasadeiFrancesco Minni
Oct 11, 2016·World Journal of Gastrointestinal Surgery·Hazem M ZakariaHoracio J Asbun
Jan 13, 2019·Journal of Surgical Oncology·Feng YangDeliang Fu
Jan 28, 2017·World Journal of Gastroenterology : WJG·Hao-Jun ShiDe-Liang Fu
Oct 25, 2017·Chinese Journal of Integrative Medicine·Meng LiPei-Tong Zhang
Sep 9, 2016·Updates in Surgery·Marco Del ChiaroUrban Arnelo
May 7, 2019·World Journal of Gastrointestinal Surgery·Kemal DolaySami Akbulut
Apr 23, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E Martin-PerezR Vera
Jan 13, 2018·Nanomedicine : Nanotechnology, Biology, and Medicine·Bowen QiAaron M Mohs
Jul 24, 2021·Annals of Surgical Oncology·Mushegh A SahakyanBjørn Edwin
Aug 15, 2021·Updates in Surgery·Riccardo CasadeiFrancesco Minni
Nov 9, 2021·Expert Opinion on Biological Therapy·Mohamed Ali ChaouchFabrizio Panaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.