Total pancreatic necrosis after organophosphate intoxication

Frontiers of Medicine
Rui HouDawei Liu

Abstract

Cases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodide. She received percutaneous catheterization and drainage of pancreatic zone to expel hazardous necrotic waste, also by which the pathogenic evidence was obtained and the antibiotics were adjusted subsequently. The patient recovered gradually, was discharged after 2 weeks, and was prescribed with oral pancreatin capsules before meals and hypodermic insulin at meals and bedtime to compensate the impaired pancreatic function.

References

Dec 31, 1997·Journal of Clinical Gastroenterology·E PanieriD M Linton
Jul 11, 2012·Toxicology International·Manjunatha GoudM Anitha
May 8, 2015·Journal of Intensive Care·Shozo YoshidaShinji Ogura

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Citations

May 2, 2019·Clinical Journal of Gastroenterology·Giovanna Del Vecchio BlancoOmero Alessandro Paoluzi
Nov 17, 2020·Frontiers in Public Health·Mbah Ntepe Leonel JaveresSyed Muhammed Nurulain

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